AAV Vector Biology and Engineering Lead

Cambridge, MA
Oct 08, 2021
Science/R&D, Biology
Required Education
Position Type
Full time

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

As the AAV Vector Biology and Engineering Lead you will oversee a small team to advance Intellia’s gene editing platform and pipeline. This role will apply new approaches to engineer and optimize AAV payloads for gene editing. This role is cross-functional and will work closely with team members in groups across the organization including disease biology, pre-clinical, manufacturing, and bioinformatics.

Key responsibilities include:

  • Manage and mentor a team working on AAV construct optimization and design

  • Develop assays for validating and optimizing novel vectors in vitro and in vivo

  • Collaborate with cross-functional teams to meet project goals and advance novel vectors into Intellia’s clinical pipeline

  • Work closely with key industry and academic partners

  • Present scientific plans and data to project teams and senior leadership

  • Manage collaborations with CROs and academic/industry partnerships, and facilitate technology/method transfer

About You:

We are seeking an innovative scientist with AAV payload design and optimization experience. The ideal candidate thrives on working collaboratively with multidisciplinary teams, displays outstanding communication skills, and is passionate about pioneering new gene-editing technologies to treat human disease. Other important qualities include:

  • Ph.D. in Molecular/Cell Biology, Genetics, Virology, Synthetic Biology, Bioengineering, or a closely related field

  • Experience with one or more of the following:

    • Design and delivery of viral or non-viral vectors

    • Virus/Host interactions and immunogenicity

    • Gene editing technologies such as CRISPR/Cas9

    • AAV delivery and biodistribution in pre-clinical models

  • Familiarity with state-of-the-art AAV research-grade production and analytical methods

  • Excellent bench skills with attention to detail and high standards for data integrity and quality

  • Hands-on experience with molecular biology methods with a desire to validate and implement new techniques

Title will be based on experience level

Meet your Future Team:

The Platform Innovation team is a collaborative, energetic, and passionate group of individuals whose mission is to advance and differentiate Intellia’s platform to enable curative therapies. You will report to a Director with vector design and production experience, and work closely with leaders in the field of CRISPR/Cas9 gene editing. The candidate will have many opportunities to broaden his or her experience with multiple cutting-edge gene therapy technologies that advance Intellia’s pipeline. 

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, the candidate must be local to Cambridge MA, or open to relocating. While some of the day-to-day operations may be home-office based, maintaining a strong relationship with your teammates is critical for conveying your scientific expertise while fostering an environment for growth of young scientists interested in a career in the biotech industry. If you join us, you can expect to be part of a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team to make a difference in patients’ lives.


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.