Senior Scientist, Preclinical Development, eDEV & TM

Location
Cambridge, MA
Posted
Oct 08, 2021
Ref
R269
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

We are excited to welcome new members to our growing Early Development & Translational Medicine (eDEV & TM) team. We are seeking a highly skilled and motivated mass spectrometrist and bioanalytical Senior Scientist to join our team. The primary responsibility for this position will be to develop mass spectrometry-based detection, characterization, and quantitation assays for a range of biological macromolecules to support CRISPR/Cas9 therapeutic development.

  • Develop new mass spectrometry-based assays to answer biological, chemical, structural, or process sciences questions for CRISP/Cas9 components

  • Develop molecule specific assays, selecting and optimizing the front-end separation technique and mass spectrometry method best suited for each analyte

  • Perform analysis of complex samples comprised of proteins, nucleic acids, lipid nanoparticles (LNP), and/or AAVs

  • Work closely with research and delivery scientists on analytical method development

  • Execute mass spectrometry-based assays to support pharmacology, BDPK, and toxicology studies of CRISPR/Cas9 based therapeutics

  • Develop assays to quantitate and execute newly defined biomarkers for CRISPR/Cas9 therapeutic candidates

  • Provide routine instrument maintenance

  • Compile assay qualifications, author bioanalytical reports, and communicate timelines and results to internal teams

  • Contribute to data-driven decisions and strategies to understand drug efficacy, safety, and mechanism of action

  • Contribute to regulatory documents to advance drug development

About You:

If you are a mass spectrometric and bench scientist interested in continuously learning new mass spectrometry methods and other analytical skills, this role is for you! A doctorate in Chemistry, Biochemistry, or a related field, is required, preferably with 2+ industry experience. Alternatively, you may hold a master’s degree in a similar field with at least 8 years of industry experience or a bachelor’s degree in a similar field with at least 10 years of industry experience. You thrive in a fast-paced environment and enjoy working both independently and collaboratively. Your strong attention to detail, exceptional time management, and strong communication skills enable you to deliver quality work.

Meet your future team:

The eDEV & TM team is a self-motivated and lively group, with an innate curiosity to explore and develop. You will report to the Associate Director of Preclinical Development. This team leads various important elements of the preclinical translational bioanalysis including data analysis, review, and communication of findings with internal and external partners.

As our group’s seventh employee, you will work closely with the larger eDEV & TM. The team has made it a priority to continue to characterize our therapeutics and their components by mass spectrometry and other analytical techniques. You will collect and analyze data that impacts the selection of programs to advance toward the clinic.

You can expect to join a hardworking, collaborative environment. The team has contributed a lot towards moving our first therapeutic to the clinic and is central to our R&D organization.

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.