DMPK Scientist

Location
94080 South San Francisco, California
Posted
Oct 08, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

POSITION SUMMARY:

Reporting to the Senior Fellow in the Department of Drug Metabolism & Pharmacokinetics (DMPK), the DMPK Scientist contributes to the design and execution of specific bioanalytical and nonclinical ADME/PK projects in the DMPK area of expertise. As a member of the DMPK preclinical development team, the individual works primarily in drug research area and in the laboratory setting. In supporting numerous discovery projects, the Scientist works independently under minimal supervision and to be proactive in suggesting and implementing new analytical technology and workflow improvements.

ESSENTIAL DUTIES AND RESPONSIBILITIES:  

  • Design, conduct and manage the execution of specific bioanalytical and ADME/PK (in vitro and in vivo) studies for multiple research and development programs
  • Develop bioanalytical assays (LC-MS/MS) for analysis of blood, plasma, urine and tissue samples for drug and metabolite concentrations
  • Prepare bioanalytical reports and presentations
  • Perform metabolism assays using hepatic microsomes or hepatocytes
  • Perform CYP450 inhibition/induction or drug transporter studies
  • Perform plasma protein binding assays
  • Perform Metabolite identification studies
  • Conduct in vitro and in vivo preclinical PK experiments, data analysis and reporting
  • Maintain data base for generated information
  • Evaluate and summarize data in a critical manner for dissemination to project team
  • Present data in group meetings or project team meetings
  • Interact with other members of the group/project teams to discuss data

 KNOWLEDGE AND SKILL REQUIREMENTS:  

  • PhD and 2 years of industry experience in Chemistry, Biochemistry, Pharmaceutical Science or a related field; or equivalent combination of degree and experience; Recent PhDs considered
  • Assay development and operation experience using LC-MS/MS
  •  Knowledge of drug metabolism, metabolite identification, CYP450 induction/inhibition assays, drug transporters, bioanalysis, ADME/PK from a variety of in vitro and in vivo matrices
  • Hands on drug metabolism and bioanalysis instrument operation experience
  • Excellent communication, organization, and presentation skills are necessary
  • Ability to conduct research both independently and in a team setting in a fast-paced environment
  • Rigel requires all employees who are working onsite at our South San Francisco location or who are in customer facing positions to be vaccinated against COVID-19 (subject to any legally required exemptions)

Rigel Pharmaceuticals, Inc. is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by the law.