Senior Principal Research Scientist

Cambridge, Massachusetts
Oct 06, 2021
Required Education
Associate Degree
Position Type
Full time
About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.


AbbVie Immunology is expanding its early discovery team in Cambridge, Massachusetts. The early Transformational and Translational Immunology Discovery (TTID) in Cambridge, Boston and Worcester is focused on identifying new targets for the treatment of autoimmune and chronic inflammatory diseases by combining expertise in both computational analysis of human disease tissue derived datasets, and through validating targets using humanized experimental approaches. We are seeking a highly skilled and dedicated individual in translational and systems immunology that drives the discovery and prioritization of new and improved projects through the portfolio through the creation, interpretation and analysis of deep molecular data. You will lead a team that will partner with multiple groups across the organization such as the Genetics Research Center (GRC) and the Functional Genomics team. This position requires passion, attention to detail, prior hands-on experience and teamwork.



Within the context of identifying new targets for the treatment of autoimmune and chronic inflammatory diseases:

  • Primary responsibility is scientific excellence in the space of systems immunology. The individual will lead a team in support of drug discovery that designs and applies of state-of-the-art immunological methodologies to understand cellular signaling in complex in vitro model systems as well as in vivo.
  • This leader will have a widespread experience in the field of immunology, immune mediated inflammatory diseases as well as systems immunology and is able to train colleagues within the department of Transformational and Translational Immunology Discovery (TTID) on this topic.
  • The individual will be a member of the therapeutic/functional area leadership team which is primarily responsible for portfolio advancement. The individual will ensure scientific excellence and the use of best practices across teams.
  • Along with Ex. Director and VP, shares responsibility for delivery of clinical candidates / technologies that facilitate delivery of clinical candidates. Identifies project targets and/or innovative technologies and prioritizes goals and milestones within the context of overall strategy, resource availability, competitive dynamics, and functional goals.
  • Department leadership responsibilities will include coordinating resources across programs, identifying and filling gaps in technology and/or capacity, sourcing and overseeing external resources, and identifying and applying new technologies. May manage several project leaders and approximately 5-10 scientists, including PhDs and Research Associates. When possible, is given the opportunity to autonomously lead key initiatives linked to therapeutic area priorities
  • The individual will manage leaders and their teams and foster scientific and professional development of staff. Accomplishes long and short-term project goals in collaboration with director, group leaders, and project team members. Exemplifies advanced knowledge, perception, and intuition across a broad range of scientific disciplines.
  • Prioritizes scientific goals, reviews data produced by team members, educates and coaches. Manages a group of approximately 5-10 scientists which includes PhDs and Research Associates. Directs one or more multidisciplinary projects. Expertise in field is sought within company and externally.
  • Positions AbbVie as a market leader and oversees the product portfolio valued by cross-functional customers. Continually defines, pioneers, and implements breakthrough solutions and technology that the industry generally accepts and utilizes.
  • Leads global industry with the international reputation as expert and key opinion leader in systems immunology and systems medicine. Participates on panel discussions at international meetings and on the standards committee for industry consortium/trade groups.
  • External/International recognition as a scientist in systems medicine / systems Immunology with recognized academic accomplishments.



  • PhD, 8+ years postdoc (academic and/or industry) experience.
  • 5+ years industry / academic experience with proven ability to innovate in systems Immunology / systems medicine.
  • 5+ years of proven leadership skills (Academic or industry); proven ability to interact well with diverse groups across functions and maintain strong working relationships with internal and external collaborators.
  • Ability to advise discipline experts and leaders across AbbVie on how to manage their particular risks.
  • Own perspective orally, in writing, and in presentations.
  • Interpersonal skills capable of negotiating and reconciling interdisciplinary differences, optimizing overall Abbvie goals.
  • External/International recognition as a scientist in systems medicine / systems Immunology with recognized academic accomplishments.

Significant Work Activities
Yes, 10 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.