Principal Scientist, Protein Interactions

Redwood City, California
Oct 05, 2021
Required Education
Masters Degree/MBA
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Our Protein Interactions Group comprised of leading experts in the biosensor field is seeking a skilled and enthusiastic Principal Scientist to help drive early-stage lead antibody discovery research for novel therapeutics at our Redwood City, CA site. The candidate will provide high quality, high impact binding and epitope characterization data in an exciting and highly collaborative environment. The candidate will report to the Protein Interactions Group lead as a senior level, laboratory-based scientist supporting a variety of oncology projects with biophysical expertise to help drive the selection and optimization of lead therapeutic antibodies.

Responsibilities include:

1) Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using surface plasmon resonance (SPR) and kinetic exclusion assays (KinExA) with sufficient rigor to both evaluate and characterize the antigen-antibody interactions under study.

2) Perform epitope binning studies using SPR.

3) Drive the development of novel biophysical assays.

4) Contribute as an essential and reliable component to help the Protein Interactions Group drive projects to a successful conclusion with a high level of motivation.

5) Interact productively with scientifically diverse research teams, including clear and concise presentation of data through oral presentations and written reports/communications.

6) Uses professional concepts to contribute to development of companys concepts and principals to achieve objectives in creative and effective ways.


Position requires a background in Biophysics, Chemistry, Biochemistry or related field with a Ph.D. and 5 or more years of professional experience, or a masters degree with 10 years or greater of relevant experience in a pharmaceutical or biotechnology research environment.

-Knowledge of surface plasmon resonance and experience with the operation of diverse SPR instrumentation

-Knowledge of KinExA experiments and experience with the operation of KinExA instrumentation

-Demonstrated ability to interpret biophysical binding data

-Demonstrated ability to communicate and present biophysical binding data to scientifically diverse teams

-Demonstrated ability to creatively solve problems related to biophysical experimental design

-Knowledge and understanding of the application of statistical principles and statistical software (e.g. GraphPad) required

-Must be highly self-motivated, detail-oriented and well organized.

-Has the ability and desire to work in a team-oriented environment.

-Experience with flow cytometry, including a background in flow cytometric antibody binding screens not required but a plus

-Experience with Octet BLI instrumentation a plus

-Crystallography experience a plus

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.