Principal Scientist, Oncology Research

Location
Durham, North Carolina
Salary
Compensation to be finalized commensurate with experience and accomplishments
Posted
Oct 05, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

Aktis Oncology is a biotechnology company pioneering the discovery and development of a new class of targeted radiopharmaceuticals to treat a broad range of solid tumor cancers. Founded and incubated by MPM Capital with its seasoned team of entrepreneurs and drug developers, Aktis has developed proprietary platforms to generate tumor targeting agents with ideal properties for radiotherapy. Designed for high tumor penetration and long residence time, Aktis Oncology’s molecules can quickly clear other areas of the body, thereby maximizing tumor elimination while minimizing side effects of treatment. These are therapies that would also enable clinicians to visualize and verify target engagement prior to exposure to therapeutic radioisotopes.

The Principal Scientist for Oncology Research will work in cross-functional teams to identify and develop novel therapies to treat targeted patient populations within multiple oncology indications. She/he will independently apply and develop cutting edge tools and methodologies to enable advancement of company objectives.  Through project leadership and experimental activities, the team member will find solutions to program related challenges in order to advance programs as part of the of the Oncology Research Team.

Background/Training:

  • Ph.D. in biological sciences or related field, preferably related to oncology or cancer biology
  • 2-8 years of biopharmaceutical research experience in drug discovery and/or translational research

Experience/Accomplishments

  • Experience with application and development of basic science methodologies to develop complex strategies and enable advancement of Company objectives.
  • Demonstrated success with the execution and interpretation of in vitro, ex-vivo and in vivo experiments to explore therapeutic potential of drug targets and drive development programs.
  • Experience leading drug discovery biology efforts to selection of lead candidates and translation into clinical development.
  • Strong technical background in planning, designing and executing pre-clinical in vitro and in vivo (required) experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates in relevant oncology models
  • Desired expertise include:
    • In vivo tumor modelling; PK/PD/Efficacy relationships
    • Imaging, microscopy or pathology experience that can be leveraged to examine target expression across cell lines and/or tissue sections
    • Mammalian cell culture / cell line engineering
    • Flow cytometry
    • Common molecular and biochemical techniques (DNA/RNA isolation, qPCR, Western, ELISA, antibody characterization and QC, etc.)
  • Preferred expertise include:
    • Biophysical characterization of targets
      • Subcellular / tissue localization
      • Target: ligand interactions
      • Target density evaluation
    • Mechanism of action studies
    • Target engagement assay development
  • Demonstrated success in the area of target discovery, target evaluation or drug discovery, translational research and integration with matrixed project teams
  • Demonstrated ability to gather relevant information systematically, break down problems into simple components and make sound decisions
  • Willingness to take on new challenges and build a culture of rigor and data-driven decision making to bring novel therapies to the clinic
  • Effectively communicates and collaborates with other R&D team members and collaborators to progress development candidate compounds
  • Demonstrated high standards for scientific rigor, team behaviors, excellence and building a culture of innovation that is fully aligned with company objectives
  • Demonstrated tenacity and drive for enterprise benefit