Senior/Principal Scientist, Antibody Discovery – Display Technologies 

Location
Seattle, WA
Posted
Oct 04, 2021
Ref
REQ-03717
Hotbed
BioForest
Required Education
Doctorate/PHD/MD
Position Type
Full time
Just is seeking a highly motivated and creative Sr. Scientist that desires a significant opportunity to help invent the technologies required to improve worldwide access to biotherapeutics. This position will be part of a cross-disciplinary team developing antibody libraries for discovery, therapeutic optimization, and high throughput characterization. A strong foundation in molecular biology, protein display technologies, and antibody domain knowledge is required for this position. Additional experience in high-throughput methodologies, bioinformatics, and protein expression is strongly desired. This individual must also possess strong communication and collaboration skills, a desire to learn new scientific concepts and domains, and an ability to work directly with scientific staff across multiple disciplines.

 

Responsibilities:

• Work independently and in teams to develop, implement, and utilize libraries for antibody discovery and optimization

• Design and execute antibody discovery campaigns using phage display to generate a diverse panel of antibodies

• Perform mammalian cell culture and transient protein expression

• Characterize antibody candidates via ELISA, AlphaLISA and other in vitro assays

• Design and construct expression vectors using standard methodologies, such as PCR, Gibson Assembly, and ligation

• Assist with the implementation and optimization of new high throughput technologies for more efficient and scalable workflows for antibody discovery

• Lead and mentor a small research group

• Maintain a detailed and organized record of experiments in an electronic notebook

• Organize, summarize, and present data and results at department and project team meetings

 

Qualifications and Education Requirements:

• B.S./M.S. with 10-20 years of experience or PhD with 5+ years of experience with training in biochemistry, cellular/molecular biology, immunology or other related discipline

• Expertise in standard molecular biology techniques (cloning, PCR, site-directed mutagenesis, Sanger sequencing, plasmid isolation)

• Experience with antibody discovery, protein libraries and display technologies

• Excellent verbal and written communication skills

• Strong focus on quality and attention to detail

• Possess effective task/time management organizational skills

• Ability to work in small groups as well as independently

 

Preferred Qualifications:

• Experience in high throughput methodologies such as automation, microfluidics, and related bioinformatics processing

• Experience in protein expression systems using multiple hosts

• Experience with NGS library construction and data analysis is strongly desired

• Experience leading a small team of scientists

Worker