Senior Scientist II Precision Medicine Immunology Translational Research- Molecular Biology

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description:

 

The Precision Medicine Department is committed to advancing drug development and patient care through building a deeper understanding of disease biology and developing tools to optimize clinical decision making and customize treatment for patients. The Senior Scientist will be part of a fast paced and multi-disciplinary team responsible for generating new scientific proposals, and leading experimental execution and data analysis.  Act as a lead scientist in their area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research and development programs. The successful candidate will have expertise in advanced molecular techniques such as next generation sequencing, fluidigm HTqPCR and instrument automation. The successful candidate will also have experience with handling human tissues and samples, and developing assays to evaluate drug target engagement, receptor occupancy and pharmacodynamics, and interrogate disease and drug biology.   The ability to work as a part of a multi-disciplinary team, represent program-related work to senior management and external collaborators will be required. 

 

Key Responsibilities:

• Maintain a high level of productivity in the laboratory
• Independently design, execute, and interpret critical experiments to answer scientific questions
• Demonstrate the ability to resolve project hurdles by utilizing available information and technical expertise in multi-dimensional cytometry
• Analyze and document results, placing data in proper scientific context through review of relevant literature and report findings at team meetings
• Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
• Understand and adhere to corporate standards regarding code of conduct, safety, controlled drugs and radioactive compounds
• May mentor/supervise a team of one or more scientists and guide and evaluate the performance of those individuals

Qualifications

Qualifications:

• Bachelor’s Degree or equivalent education and typically 12 years of experience, Master’s Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience
• Possess thorough and practical understanding of own scientific discipline
• Expertise in next generation sequencing
• Strong experience with instrument automation for library preparation (Beckman Biomek i7)
• Experienced in RNAseq, methylation sequencing, automated RNA isolation
• Experience working with human tissues
• Experience with scRNA-seq or CITE-seq is a plus
• Experience with ex vivo culture of human tissues, cell biology/flow cytometry techniques and/or ligand binding assasys is a plus
• Knowledge of basic immunology concepts
• Ability to work with multidisciplinary groups in a fast-paced discovery team setting
• Effectively communicate cross-functionally with team members throughout the organization
• Demonstrated ability to communicate effectively (both written and oral)

Equal Opportunity Employer Minorities/Women/Veterans/Disabled
 

Additional Information:

• Travel: 5-10%
• Job Type: Experienced
• Schedule: Full-time

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
Yes, 10 % of the Time
Job Type
Experienced
Schedule
Full-time
Job Level Code
M
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.