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Scientist, Therapeutic Genome Editing (Multiple Openings)

Employer
Mammoth Biosciences
Location
Brisbane, CA
Start date
Oct 2, 2021

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Discipline
Clinical, Science/R&D, Biotechnology, Genomics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay

Job Details

OPPORTUNITY
Mammoth is seeking a Scientist with expertise in therapeutic genome editing. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in primary cells and disease models. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals. 
KEY RESPONSIBILITIES
  • Initiate, direct, and perform experiments to evaluate novel genome editing systems
  • Advance the application of novel CRISPR systems for human therapeutics
  • Manage direct reports and collaborate with others on the team
  • Record, document, analyze and communicate scientific data to senior staff and team members and participate in the writing of SOPs, report, and manuscripts for publications

REQUIRED QUALIFICATIONS
  • Ph.D. in relevant field with 3+ years relevant experience
  • Strong background in molecular biology, cell engineering, gene and cell therapy
  • Experience with genome editing for human therapeutics
  • Experience with viral and/or non-viral delivery methods (such as AAV and LNP)

PREFERRED QUALIFICATIONS
  • Demonstrated expertise with CRISPR for human therapeutics
  • Experience with characterization and optimization of CRISPR systems
  • Experience working with primary cells, iPSC and complex cell culture systems
  • Experience with AAV vector optimization and production
  • Experience with NGS to characterize CRISPR editing efficiency and specificity
  • Strong communication, presentation and data analysis skill

BENEFITS
  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching

Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.
 
TEAM
Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Company

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

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Company info
Website
Phone
(650) 294-8583
Location
South San Francisco
CA
94080
United States

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