Associate Director, Cellular Therapy
Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in preclinical development for the treatment of patients with metastatic melanoma and other solid tumors.
We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our research team is based in the heart of Cambridge, MA, and our Technical Development and Manufacturing will soon be moving to a brand new facility in Bedford, MA to support our growth. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
We’re looking for a highly motivated, creative, collaborative, flexible scientist and leader to join the Cell Therapy Department as a key contributor to preclinical research to oversee development of new pipeline programs. As part of our Cell Therapy research department, you’ll be a vital part of a highly collaborative team working to achieve Obsidian’s vision by translating innovative science into medical breakthroughs for patients, starting with our lead program cytoTIL15 engineered to make TILs more effective for more patients.
This is a unique opportunity in a well-funded pre-clinical biotech with blue chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in oncology and other areas of greatest clinical need. Obsidian is an equal opportunity employer.
Lead preclinical proof of concept research activities toward the development of cell therapy products
Generate and vet creative ideas for new cell therapy product concepts, recommend pipeline priorities, and facilitate buy-in and support of senior leadership
Build focused workplans to prioritize pipeline candidates
Build, lead, train, and mentor an engaged and high performing team of scientists and research associates in the design, execution, and analysis of experiments to support externally partnered and new pipeline programs
Mentor scientists to become project leaders and effective managers
Engineer human T cells and TILs, develop and apply cell-based immune assays, including co-cultures with other immune cells
Work closely with the Discovery team to conceptualize new candidates and design and execute screening for lead optimization
Work closely with the In Vivo Pharmacology team to design and analyze in vivo adoptive cell transfer studies
Present results at internal and external meetings
PhD in immunology or a related field with 3+ years postdoctoral training and 4+ years of industry experience
Experience leading and developing a diverse and high performing team of scientists
A track record of success in driving cross-functional research projects in industry, from concept through execution
Deep expertise in ex vivo immunology methods including human and mouse T and NK cell isolation and genetic engineering, functional assay development using techniques such as multi-color flow cytometry, cytotoxicity assays, cytokine quantitation, coculture and proliferation assays
Scientific rigor in the design, execution, analysis, and troubleshooting of experiments
A team mindset and highly collaborative working style
A flexible and creative mindset; a continuous learner, able to productively challenge and be challenged to generate the best ideas to advance project and company goals
An ability to operate and adapt in a fast paced, rapidly developing environment
Experience translating high level goals into plans, and independently leading teams to meet objectives and timelines, adapting to changes and priorities in order to fulfill our mission
Excellent organization, record keeping, and communication skills
Experience with viral vector transduction of primary human immune cells and cellular immunotherapy
Experience with tumor infiltrating lymphocytes (TIL) would be a plus
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.