Associate Scientist, Flow Cytometry
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.What You Will Achieve
Incumbent will be responsible for testing samples for pre-clinical and early stage (Phase I) clinical studies as a member of the Clinical & Diagnostic Assay Development Group (CDAD). The candidate will also be responsible for maintenance and upkeep of multiple flow cytometers. The role is focused on flow cytometry assays but also includes performance of other cell-based assays on clinical samples. The role requires an in-depth technical knowledge of multi-parameter flow cytometry and good understanding of relevant software including FACS Diva and FlowJo. Experience of working in a BSL2 level tissue culture laboratory is required, as well as an understanding of cellular immunology and the key assay platforms of flow cytometry and ELISPOT. The role requires good analytical skills, attention to detail and the ability to clearly document and present complex biological data. Incumbent is required to multitask and work as part of a team that is required to meet business-critical deadlines.How You Will Achieve It
Conduct flow cytometry assays in accordance with GCLP requirements.
Analyze, document and report experimental data in accordance with Pfizer/GCLP requirements.
Applying systems thinking, problem-solving, debugging, and troubleshooting to generate innovative ideas to improve processes.
Support the efficient and compliant operation of the laboratory by developing appropriate processes and standard operating procedures, working with others to operate the laboratory, and by becoming an expert user in key areas of operation (such as LIMS and GDMS).
Assist in the sourcing and maintenance of reagents required to conduct clinical flow cytometry assays in a compliant manner.
Maintain and build a broad knowledge of key assay platforms (including flow cytometry and ELISPOT assays) and the scientific rationale underpinning the assays through appropriate training and self-learning.
Bachelor's degree with at least 2 years of relevant work experience or Master's degree with at least 1 years of relevant work experience.
Experience in working with human and murine samples.
Experience working in a tissue culture laboratory with samples requiring BSL2 containment.
Experienced in developing and conducting flow cytometry based assays.
In depth experience with flow cytometry (Fortessa and/or Cytek Aurora).
Experience of working in a GCLP-compliant environment.
Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.
Proficiency in high-parameter immune phenotyping of immune cells (isolated from mouse and/or human tissues) by Flow Cytometry (comfortable running at least 10-color panels, including intracellular staining).
Experience in assessing T cell function, differentiation, and memory development.
The position has physical requirements of basic office and laboratory work (sitting, standing, and walking).
The mental requirements include the ability to analyze data, design experiments, and present complex concepts to colleagues.
Other Job Details
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.Research and Development