Principal Research Scientist II, Immuno-Oncology Discovery

Redwood City, California
Sep 29, 2021
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Since 2013, AbbVie has expanded its commitment to the San Francisco Bay Area, now represented by three facilities in Redwood City, South San Francisco, Sunnyvale and a future new Bay Area headquarters in South San Francisco. AbbVie employees in the Bay Area drive AbbVie’s research-based, innovation driven missions in healthcare. Specifically, Bay Area employees bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we are able to collaborate with the best and brightest minds in oncology.

AbbVie’s Immune Oncology research group sits within the Oncology Discovery organization and identifies novel assets that restore anti-tumor immunity for treating heme and solid tumors.

As a Principal Scientist l, Immune Oncology Discovery you will identify and lead promising new research opportunities in T cell biology. You will leverage internal and external resources by working closely with teams across multiple locations and teams including development, clinical and other groups to develop AbbVie’s Oncology pipeline.

  • Responsible for target identification and therapeutic molecule development
  • Leading and executing scientific research of early stage immune oncology discovery programs and developing strategy in moving those programs through internal milestones towards IND filing.
  • Develop innovative in vivo/ex vivo/in vitro assays/analyses to interrogate the function of immune and tumor cell populations and their interaction
  • Recognized and sought out as an expert in T cell biology within the company and externally.
  • Resolving key project hurdles with available information from literature and internal or external experts
  • Generating scientific proposals and maintaining a high level of productivity in the lab
  • Promoting AbbVie scientific reputation through writing reports, making external presentations, and publishing original discovery in peer-reviewed journals.
  • Mentoring/supervising a group of scientists and evaluating the performance of those individuals



  • Position will be filled based on level of experience
  • Bachelor’s Degree in Science related field with 16 years of related work; Master’s Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience.
  • 6+ years postdoc/industry experience with track record of scientific accomplishments and delivering high quality clinical candidates, as evidenced by INDs, patents and publications
  • Demonstrated accomplishment as scientific leader in large molecule drug discovery and development, such as fusion protein, monoclonal antibodies, bi-specific molecules, and antibody drug conjugate.
  • Strong capability of doing multicolor flow cytometry analysis, proficiency in performing data clustering with different software and familiar with single cell related technology
  • Excellent skills in conventional immune assays and capability of developing comprehensive culture models containing immune cells and tumor cells
  • Experience in using various types of in vivo models to test IO therapeutics.
  • Excellent communication skills, both oral and written



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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.