Principal Scientist, Medicinal Chemistry

Redwood City, California
Sep 29, 2021
Required Education
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Experienced medicinal chemist who is seeking a new challenge as a project leader in an interdisciplinary team and who is interested in leading and mentoring a group of direct reports.

Job Title/Description

We are seeking an exceptionally talented and highly motivated medicinal chemist who is passionate about joining our fast-paced medicinal chemistry group in the pursuit of discovering innovative therapies in Oncology. A strong proficiency in fundamental aspects of drug discovery and demonstrated ability to lead or co-lead multi-disciplinary discovery programs and advancing them to critical milestones is required. She/he will contribute to programs by setting strategies, priorities, and driving critical path drug discovery objectives. The candidate should have relevant supervisory experience with internal direct reports as well as external CROs. Candidates must have experience in the independent design and execution of multistep syntheses of complex organic molecules using modern organic chemistry. Excellent hypothesis driven problem-solving skills and a thorough understanding of medicinal chemistry principles, synthetic methods, and reaction mechanisms are required. Candidates will have expertise in the purification and characterization of organic compounds. Excellent oral and written communication skills and a desire to work in a collaborative team environment are required. A track record of innovation documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals is necessary. Knowledge in E3 ligase and UPS biology is a plus as protein homeostasis is one of the fundamental research engines at BMS delivering therapeutics to patients. Not being bound by therapeutic modality creates a very dynamic, exciting and creative environment where the successful chemist will interface with an excellent team of scientists in biology, biochemistry, structural biology, computational biology and translational development.


  • Ph.D. with 4+ years of medicinal chemistry experience in a pharma or biotech environment
  • M.S. degree with 10+ years or a B.S. degree with 12+ years of industrial medicinal chemistry experience.
  • Track record of innovation and impact on programs documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals (may include both successful advances and smart terminations).
  • High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods, and reaction mechanisms are required.
  • Committed to experimental work skilled in multi-step synthesis, purification, and state-of-the-art techniques for characterization of organic compounds.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents or conferences and using this information to guide program strategy.
  • Experience with supervising Ph.D. and associate level scientists to high levels of productivity, whilst improving the skills and knowledge of direct reports through mentorship.
  • Broad knowledge of the drug discovery and development process.
  • A naturally collaborative style as necessary to work effectively in a fast-paced, highly integrated team environment.
  • Excellent written and oral communication skills demonstrated ability to write peer reviewed quality work or invention disclosures for patent applications, and able to present the rationale, key data, issues and accomplishments department wide.

Preferred Qualifications

  • Experience working in the field of protein degradation and understanding of E3 ligase biology

Travel Required

  • Local and international travel for conferences and regulatory meetings may be required depending on project needs up to 5-10% of the time

Fit with BMS Culture and Values

  • Diversity, inclusion and integrity
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

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