Senior Associate Scientist, Histopathology
At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines, we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.
We are seeking a highly motivated and talented individual to join the Immunohistochemistry (IHC) team in the Translational Research Group at Bristol Myers Squibb (Redwood City, CA). The Scientist will be part of a team dedicated to developing various tissue-based assays to drive discovery programs and enable translational biomarker strategies in multiple oncology programs. The ideal candidate will possess in-depth histopathology laboratory skills and experience, including tissue processing and embedding, automated IHC staining, IHC validating research using IHC markers for brightfield and multiplexed immunofluorescence assays. He/she will also have strong communication skills, ability to work in a matrixed-based, fast paced environment, solid problem-solving abilities, excellent organizational skills and attention to detail and a commitment to excellence.
Duties & Responsibilities will include, but are not limited to, the following:
Perform assigned histology and IHC staining under minimal supervision by organizing own workload and following study protocols; produce high quality histological slides and complete all study activities on time.
Perform all work efficiently in a safe manner and in compliance with applicable regulations.
Perform routine preventative maintenance, cleaning, and minor adjustments on lab equipment; demonstrate ability to trouble-shoot equipment without supervision.
Document all work activities and maintain all assigned study records in accordance with study protocols by following company policies, using current forms and procedures, making all entries legibly, correctly and contemporaneously in a timely fashion.
Provide training and technical guidance to team members when needed.
Effectively collaborate in highly matrixed organization.
Retrieve and store specimens properly for long term storage; maintain archived histological slides and blocks.
Assist in the ordering of laboratory supplies to maintain proper inventory.
Understand and use proper safety practices. Complete all company required training and compliance courses.
Perform other duties as assigned.
Bachelors degree from an accredited institution in a relevant scientific field with 5-10 years of experience or Masters degree with 2-10 years experience in the conduct of histotechnology either in an industry or in a clinic/academic core lab.
Extensive hands-on histopathology laboratory experience, including human and rodent tissue grossing, operating automated tissue processors, performing paraffin embedding of tissue blocks and cell pellet blocks, performing IHC and in situ hybridization using autostainers (Leica Bond, Ventana, DAKO, etc.), and operating whole-slide scanners (Leica AT2, etc.)
Extensive experience in FFPE microtome and frozen tissue cryostat sectioning.
Experience with validating chromogenic and fluorescent staining (including Opal Dyes) on pre-clinical, non-clinical and clinical samples.
Experience working with service providers and CROs in the histology industry.
Experience with Microsoft Office software suit (Excel, Word, PowerPoint, Outlook).
Excellent organizational skills and attention to detail.
Ability to work independently under minimal supervision.
Excellent written and verbal communication skills; concise and accurate reporting of information
Must be able to work in a seated position for an extended duration (~2h), with periodic breaks, while performing routine histotechnology functions (eg., tissue trimming, embedding, microtomy, etc.)
American Society of Clinical Pathology Certified (or eligible) Histotechnician (HT) or Histotechnologist (HTL) is highly desirable.
Some experience with digital pathology image analysis software (HALO, etc.).
Knowledge of tumor pathology, cancer biology and immuno-oncology is a plus.
Previous industry experience in a GLP regulated environment or clinical diagnostic histopathology lab is a plus.
Familiarity with a matrixed based, fast-paced work environment.
Collaborative spirit and ability to thrive in a matrixed environment.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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