Process Scientist, Upstream Early Pipeline Development

Location
San Diego, CA
Posted
Sep 28, 2021
Ref
2021-6297
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time

INNOVATION, QUALITY, COLLABORATION, PERFORMANCE, COURAGE AND INTEGRITY

 

Over 900+ clinical trials validate that gene therapies are transforming the practice of medicine. As a Senior Scientist for AAV early pipeline process development, you will have an opportunity to join the NIBR Biologics Center (NBC) and be at the cutting edge, leading the development of innovative medicines that can improve lives of patients.

 

NBC builds the biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics. The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.

 

The Process Scientist, Upstream Early Pipeline Development, develops innovative engineered cell line for next generation AAV gene therapy manufacture.  The candidate will also be responsible for executing early-stage process development with the focus on developability for early-stage AAV gene therapy pipeline portfolio as well as new platform process for existing and novel AAV capsids and cargo vectors.

Responsibilities

  • Execute adherent and suspension small-scale bioreactor-based cell culture processes for manufacturing of AAV gene therapy vectors across multiple preclinical programs and disease areas to ensure on time delivery.
  • Lead collaboratively in operational and strategic discussion within a global team.
  • Design and execute experiments to drive innovative technology and platform evaluation for next generation capsids and cargo vectors and work collaboratively with downstream process development and analytical development teams.
  • Serve as interface with downstream, Disease Areas and platform/technology teams to drive early drug discovery from target selection and validation through lead compound selection and developability assessment
  • Work collaboratively with Cell Line Development team to develop stable producer cell line for next generation AAV manufacture.
  • Serve as an interface to transfer knowledge and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
  • Provide technical support, training, and SME knowledge to assist with the development of junior associates.
  • Prepare protocols, reports and provide high quality data and electronic notebook documentation.
  • Other related job duties as assigned.

Qualifications

  • B.S. biology, biochemical engineering, bioprocessing, pharmaceutical sciences, or related technical field, Master's degree or PhD preferred.
  • Industry experience is required.
  • Prior experiences developing novel upstream process for recombinant proteins and antibodies or early-stage AAV or other viral vector manufacturing and/or process development is required.
  • Experience in operating adherent/suspension culture bioreactor, microbioreactor (e.g. ambr) and single-use small scale stirred-tank bioreactor experiments for mammalian cell culture.
  • Design of experiments (DoE)
  • Effective communication including presentations to convey scientific concepts to research scientists and cross-functional collaborators.
  • Individual team player who demonstrates technical proficiency and creativity, collaboration with others and independent thought. Ability to work in a matrix environment.
  • Strong organization, analytical, and problem-solving skills with attention to details.

 

The level of this position will be based on the final candidate's qualifications. 

 


Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.


We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying!  Imagine what you could do here at Novartis!


Novartis Gene Therapies Benefit Summary:

Annual bonus, long term incentive, health insurance, paid vacation/holidays, potential flexible working arrangements (based on role) and an employee recognition program are available for this position, among many other benefits provided to employees of Novartis Gene Therapies.

 

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

 

Novartis Gene Therapies is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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