Director, Medicinal Chemistry

Location
Palo Alto, California
Posted
Sep 27, 2021
Discipline
Science/R&D, Chemistry
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
Who You Are:

Do you want to be a part of the next-level discovery team to test “moonshots” in genetic disease at BridgeBioX? We seek entrepreneurial scientists to work on high-risk, high-reward programs. The successful candidate will be a results-driven scientist with extensive experience in Medicinal Chemistry and a keen understanding of the drug discovery process. They will partner with experienced drug hunters, CROs, and academic collaborators to deliver IND-ready candidates for clinical testing. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment.

You will lead and contribute to the discovery and development of therapeutics in some of the most challenging and high-impact research areas.

About BridgeBioX and BridgeBio Pharma

Leveraging extensive inherited disease experience and an established drug development infrastructure, BridgeBio recently formed a discovery research group called BridgeBioX. The vision of BridgeBioX is to use cutting-edge biology to develop breakthrough medicines in genetic diseases with high unmet needs across multiple therapeutic areas including oncology, neurology, pulmonology, and cardiology. BridgeBioX is building out lab space on the Stanford Life Sciences campus to create a hybrid industry-academic environment where scientists from the top labs around the world can collaborate with senior BridgeBio leadership and advisors.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at https://bridgebio.com

Responsibilities:
  • Lead Medicinal Chemistry efforts for BridgeBioX small molecule drug discovery programs
  • Design and execute medicinal chemistry strategies in an outsourced environment. Manage synthetic chemistry CROs to deliver high-quality data in a timely manner
  • Interpret biological and ADME data and design novel compounds that possess increasingly druglike profiles
  • Collaborate with academic researchers to leverage external knowledge
  • Manage interactions with cross-functional team leaders to support compound progression
  • Develop, implement, and deliver on team collaborations: including initial proposal development, planning timelines and resources, monitoring milestones and final deliverables
  • Provide well-organized reports and presentations to project teams and senior management
  • No matter your role at BridgeBio, successful team members are:

  • Patient Champions, who put patients first and uphold strict ethical standards
  • Entrepreneurial Operators, who drive towards practical solutions and have an ownership mindset
  • Truth Seekers, who are detailed, rational, and humble problem solvers
  • Individuals Who Inspire Excellence in themselves and those around them
  • High-quality executors, who execute against goals and milestones with quality, precision, and speed


Education, Experience & Skills Requirements:
  • Ph.D. in synthetic organic chemistry or medicinal chemistry with 10+ years of drug discovery experience in the biopharmaceutical industry
  • Demonstrated record of advancing multiple drug discovery programs from target validation through clinical candidate selection as evidenced by INDs, first-author publications, grants, patents, scholarships, or awards
  • Knowledgeable and skilled in designing and conducting vast arrays of assays to characterize compounds
  • Experience in managing diverse and multiple CROs
  • Experience in structure-based drug design and optimization of ADME/PK properties
  • Strong communication skills (verbal and written) and presentation skills


What We Offer:
  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision – both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard


We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.