Principal Scientist- Internal Medicine Research Unit
The Internal Medicine Research Unit’s (IMRU) goal is to build a world class research team of dedicated scientists committed to developing a deep mechanistic understanding of the metabolic pathways underlying disease pathogenesis. As a member of the discovery biology team, you will be playing a significant role in the drug discovery process including ideation and hypothesis testing, identification and validation of therapeutic targets and disease related biomarkers.
The key strategic focus area is identifying novel therapies to prevent or treat diseases associated with diabetes or the metabolic syndrome including NASH, obesity, renal disease and heart failure. Similarly, another interest is the treatment of syndromes of unintended weight loss, such as the anorexia/cachexia syndrome that often accompanies cancer or chronic disease.
In addition, the individual will build and facilitate collaborations with partners in the academic scientific community, as well as within the larger Pfizer network. She/he will have daily interactions with a team of creative and innovative scientists, working collaboratively in a supportive environment to conduct rigorous scientific and drug discovery research.
The successful candidate will lead a team of experimental scientists as well as collaborate effectively with a wide spectrum of scientific partners representing diverse disciplines. Knowledge and experience in the study of metabolic pathways are essential and familiarity with the pathophysiology of dysmetabolic states would be advantageous.
Successful candidates will be expected to:
- Apply creative thinking and scientific expertise to the formulation of strategies to identify and validate therapeutic targets in key areas of interest to the Internal Medicine Research Unit.
- Maintain a awareness of ‘cutting edge’ scientific and technical developments in preclinical to clinical translation and apply these where possible to advance the portfolio programs.
- Conceptualize and design experiments.
- Mentor junior scientists in developing skills essential to the execution of rigorous scientific research
- Organize and conduct in vivo/ ex vivo/ in vitro studies independently (including experimental design, data collection, interpretation, and presentation).
- Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.
- Build and facilitate collaborations with partners in the academic scientific community, as well as within the Pfizer network of scientists.
- Present research findings to Pfizer colleagues and the scientific community through publication in peer-reviewed journals and talks and posters at scientific meetings.
- Present and represent research programs to Pfizer leadership.
- Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines.
- PhD with successful postdoc training and additional 3+ years of research experience in academia and/or industry in the relevant field.
- Demonstrated ability to review critically available data and to think creatively in formulating novel hypotheses.
- Successful record of scientific accomplishments as indicated by scientific publications and presentations.
- Deep expertise in metabolism and/or signaling pathways.
- Experience in performing in vitro, in vivo and ex vivo experiments.
- The candidate should be able to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
- Demonstrated ability to contribute to multiple projects in parallel with learning agility and scientific rigor.
- Strong written/verbal communication skills and ability to collaborate effectively with scientists working in other disciplines.
- Strong self-motivation
- Ability to both lead as well as work as part of a team are essential
Other Job Details:
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