Senior Associate Scientist (non-PhD), Translational Sciences Immunopharmacology
We are seeking an enthusiastic Senior Associate Scientist to join the Translational Sciences Immunopharmacology group within the Oncology Research Unit (ORU) of Pfizer’s Worldwide Research & Development (WRD) division in La Jolla, California. The successful candidate will join a dynamic team of scientists, playing a leading role in the characterization of models of cancer and evaluating new immune-oncology drug candidates. Participate in pre-clinical drug discovery and development projects with a focus on immune-oncology and the tumor microenvironment. Characterize and develop small and large molecules in close collaboration with partner lines as an integral member of drug discovery teams. Employ and develop new cutting-edge in vivo cancer models and provide technical and scientific expertise in in vivo pharmacology to the Oncology Research Unit to enable target identification, validation, prioritization, and efficient drug discovery of small and large molecules.
Working as a key member of an in vivo team, perform a range of in vivo studies that generate critical project data for project teams. The Sr. Associate Scientist is a technical and scientific specialist in the conduct of oncology in vivo studies and will be responsible for: study planning, scheduling and execution, sample preparation and collection, appropriate documentation and accurate exporting, formatting and presenting data for multidisciplinary project teams. The in vivo Sr. Associate Scientist will work collaboratively with all in vivo team members and project teams to understand their needs, obtain the necessary approvals and deliver in a timely and efficient manner.
Ideal applicants will have excellent communication and organizational skills, critical problem-solving abilities, strong independence and a commitment to excellence.How You Will Achieve It
- Assist/Conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
- Interpretation, presentation and documentation of experiments.
- Collaboration in a multidisciplinary team environment.
- Keep up with the current literature and implement learnings in the study designs or project strategies.
- Perform ancillary in vitro and ex vivo assays to characterize effects of experimental medicines that may include FACS, scRNAseq, tissue culture assays, Western Blotting, ELISAs or other assays as needed.
- Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards
- Efficient communication with CROs, including study design, interpretation and documentation of studies run externally
- Bachelor of Science degree in Biology, Immunology, Oncology or similar, with 3+ years’ relevant experience or Master’s with 0-1 years’ experience.
- Current knowledge of oncology, immunology, and immune-oncology, drug discovery and development.
- Experience with animal models of human cancers.
- Hands on in vivo skills (PO, SC, IP, IV dosing), cell implantation, blood/tissue collection.
- Excellent written and oral communication and presentation skills.
- Proficiency in all common office and scientific software.
- Ability to follow novel scientific or technological developments and to implement them in the laboratory.
- Strong ability to multi-task and work productively in a fast-paced, highly collaborative and diverse team environment.
- Capability to contribute to a vivid and challenging intellectual environment.
- Experience/proficiency in flow cytometry.
- Experience with humanized mouse models.
- Experience with StudyLog.
- Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
- Must be willing and able to work after hours as needed to ensure study integrity.
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