Senior Research Associate I- Protein Sciences

Location
San Diego, CA
Posted
Sep 23, 2021
Ref
540883
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time

Position Summary

AnaptysBio has an exciting opportunity for an Associate Scientist to join the Protein Sciences group to support antibody discovery and biophysical characterization activities. This includes using a broad range of analytical, biophysical, and computational tools to characterize antibodies, antigens, and their interactions. The ideal candidate will have interest in protein structure and biophysics, a keen sense of scientific curiosity, and the ability to interact in a matrix environment with members of other groups.

  Essential Functions

  • Perform protein interaction kinetics experiments (SPR, BLI, KinExA) for antibodies, antigens, and reagents.
  • Independently analyze experimental data and troubleshoot difficult experiments.
  • Determine and validate new methods and procedures. Able to perform critical analysis of experimental approach and interpretation of data.
  • Biophysically characterize antibodies, antigens, and reagents using a variety of analytical tools such as DSC, cIEF, CE-SDS, and DLS.
  • Participate in antibody engineering and humanization activities; develop an expanding knowledge in this area using scientific literature.
  • Maintain detailed organization of experimental results to inform project decisions. Ability to summarize key data, and present at project team meetings.
  • Maintain familiarity with literature to propose and implement improved procedures and protocols, and to aid in problem solving.
  • Follow and adhere to SOPs and laboratory safety regulations. 
  • Mentor junior and new laboratory personnel.
  • Maintain a detailed and well-organized record of experiments in an electronic notebook.

  Personal Competencies

  • Ability to communicate clearly, and to report and present experimental results and analysis to department colleagues.
  • Effective interpersonal skills, strong team player.
  • Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment.
  • Demonstrated ability to independently perform laboratory tasks safely, reproducibly, and efficiently.
  • Ability to organize work-load and activities to achieve team goals.
  • Self-motivated, independent, and results-oriented.

Physical Demands

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to sit and talk or hear. The employee frequently is required to use hands to finger, handle, or feel. The employee is occasionally required to stand, walk, and reach with hands and arms. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision and ability to adjust focus in order to read.

Work Environment

The work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This position requires working with biological and/or chemical hazards.

Requirements

  Education and Experience

  • BA/BS degree in biology, biochemistry, or a related field.
  • 5+ years of relevant laboratory experience.

Knowledge Requirements

  • Working knowledge of antibody structure/function.
  • Experience with Biacore T200, S200, and/or 8K instruments is highly desired.
  • Experience with antibody biophysical characterization and developability assessment.
  • Familiarity with protein modeling/visualization software (i.e. PyMol, Bioluminate, etc).
  • Experience with HPLC analysis of purified recombinant proteins is a plus.

 All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.