Sr Scientist I, Precision Medicine Oncology

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

The Precision Medicine (PMed) Translational Oncology group is committed to drive translational and biomarker efforts for our pre-clinical and clinical stage programs. The translational research group is a critical component of the Abbvie Oncology department and is comprised of a multi-disciplinary team of scientists with diverse skill sets, generating key datasets to inform clinical decisions including patient selection and MOA validation. We are seeking a highly motivated Senior Scientist with a strong scientific background in immunology / cancer biology, passion for translational research, and a proven track record of research accomplishments to join this dynamic team.  The successful candidate will work both within the Translational Oncology group and as a member of cross-functional interdisciplinary teams. The candidate is expected to design and execute experiments independently to enhance our translational and biomarker research.

RESPONSIBILITIES INCLUDE:

• Independently devise, execute, and analyze hypothesis-driven translational research experiments to inform patient selection, mechanisms of resistance, identify PD biomarkers, and test novel drug-combinations to advance the Abbvie oncology pipeline.
• Routinely utilize broad technical expertise in tumor cell/immune cell biology ex-vivo and in-vitro assays to advance translational research for both pre-clinical and clinical stage oncology projects.
• Initiate and maintain collaborations with cross-functional teams such as in-vivo, bioinformatics and DMPK to ensure alignment on scientific rationale and data generation workflows.
• Effectively communicate hypotheses, work plans and data generated to diverse audiences in both oral and written communications.
• Train and guide colleagues on established methodologies, troubleshoot assays and establish novel techniques within Abbvie or at CROs.

Qualifications

Senior Scientist I: PhD with 2+ years of experience, Master’s degree/equivalent education and 8 years of experience or Bachelor’s degree/equivalent degree and 10 years of experience.

• Exceptional technical precision using standard immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, etc.) primary cell culture, tissue processing, as well as standard molecular biology and biochemical techniques.
• Ability to:
  • Demonstrate and implement critical thinking skills.
  • Learn, understand, and master new areas of biology and experimental techniques.
  • Articulate scientific rationale with clarity.
  • Work independently and proactively on multiple projects in a fast-paced environment.
  • Ability to thrive in a multi-disciplinary, matrixed environment.

• Expertise in oncology, cancer signaling pathways, prior exposure to translational research/biomarker discovery, human immunology and immunotherapy.

PREFERRED QUALIFICATIONS:

• M.D. and/or Ph.D. in immuno-oncology or related field with at least 3+years of relevant postdoctoral cancer research experience in academia or pharma industry.
• Experience with cell line engineering, cancer genomics and transcriptomics.
• Demonstrated excellence and productivity in independent research.

• Hands-on experience in generating and analyzing multi-parameter gene and protein datasets is highly desirable (RNASeq, Nanostring, high-dimensional FACS, scRNASeq, etc.)

Be versed in the current state of the science of the tumor microenvironment and the interplay between immune cells, stroma, and tumor cells.

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.