Scientist / Technical Scientist, Capsid Engineering, Gene Therapy Research

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

• This is a wet lab-based position. The person will work with the team to construct and characterize different AAV capsid variants in lab. The capsid variants are either designed to map out the critical functional sites or for developing novel vectors with desired phenotypes.

position requirements:

• Hands on experience with AAV gene therapy, capsid rational designs or capsid functional sites mapping is a great plus
• Have background knowledge on AAV biology or structural biology is a great plus
• Strong organization skills and ability to multi-task efficiently in a dynamic environment
  Demonstrated success working as a team player with good verbal and written communication skills
• Analytical and problem-solving skills
• Attentive to details and be able to deliver reliable results consistently
• Good record tracking and maintain detailed electronic lab notebook
• Strong work ethic and a collaborative team player

• Hands-on lab experience in molecular biology, cell biology, biochemistry techniques:
  • Molecular biology: Gibson assembly, Cloning techniques, Primer design, PCR, qPCR, RT-qPCR, ddPCR, Nucleic acid purification, Illumina library preparation, NGS data analysis.
  • Cell Biology : cell line work and primary cell work, transfection and transduction
  • Protein Biology/ Biochemistry: ELISA, SDS-PAGE, Western, dot-blot, affinity column
  • Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated

EDUCATION:

• PhD/MS/BS with a specialization in molecular biology, virology, cell biology, biochemistry or related disciplines 

TITLE REQUIREMENTS:

• Scientist 1:   PhD or equivalent relevant experience, plus 0-2+ years industry experience

• Technical Scientist 1:  Bachelor’s degree and at least 10 years of experience; Master’s degree with at least 8 years of relevant experience

• Senior Research Associate 2: Bachelor’s degree and at least 8 years of experience; Master’s degree with at least 6 years of relevant experience

EQUIPMENT:

• Common molecular/protein biology BSL1 lab equipment & tissue culture BSL2 equipment.

CONTACTS:

• Must be able to work in a team format.

SUPERVISOR RESPONSIBILITY:

• No directs reports associated with this position

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.