Formulation Scientist

Position

Nurix is looking for a Scientist in the drug product division to provide scientific, technical, and hands-on support of drug discovery and product development related to orally administered small molecules.

Duties/Responsibilities

• Perform and oversee formulation development for preclinical, non-clinical and clinical studies.
• Oversee outsourcing of analysis, development, manufacture, tech transfer and scale-up of formulations.
• Build and analyze large data packages to support regulatory filings, including in-house and outsourced characterization.
• Coauthor regulatory filings for all stages of development.
• Work closely with cross functional team to ensure on-time delivery and rapid development of clinical phase products to registration: preclinical development, analytical chemistry, chemical development, program management, supply chain, clinical pharmacology, and clinical sciences.
• Travel as needed to transfer processes and observe manufacturing.

Required Skills/Abilities

• Experienced in formulation and process development, manufacture, and scale-up of oral solid dosage forms of small molecules.
• Knowledge and familiarity with manufacturing techniques and equipment: milling, blending, roller compaction, wet granulation, fluid bed processing, hot melt extrusion, encapsulation, compression, and coating.
• Experience in safe handling of potent compounds.
• Knowledge of analytical techniques: HPLC/UPLC, XRD, Raman, Dissolution, FTIR, Disintegration, material characteristics (surface area, particle size distribution, density, solid fraction, hardness, friability)
• Experience in cGMP environment and knowledge of 21CFR.
• Working knowledge of guidance from FDA, EMA, and ICH.
• Experience with regulatory filings a plus.
• Knowledge of HPLC software, Empower and MassLynx a plus.
• Proficient with Microsoft 365
• Experience in large data sets, data presentation and modelling a plus. (eg R, python, JMP®, Minitab®, Spotfire®, Gastroplus®, winNonlin®, nonmem)

Education and Experience

• PhD in physical sciences or pharmaceutical sciences with 2+ years of industrial experience
• Bachelor’s or Master’s degree in physical sciences or pharmaceutical sciences with 6+ years of industrial experience

Physical Requirements

• Ability to work in laboratory.
• Ability to travel and wear appropriate PPE for site visits.
• Prolonged periods of sitting at a desk and working on a computer may be required.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.