Principal Scientist, In Vivo Pharmacology and Tumor Models

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Adicet Bio, Inc. is a biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer and other diseases. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors and T cell receptor-like antibodies to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients. For more information, please visit our website at http://www.adicetbio.com.

PRINCIPAL SCIENTIST, IN VIVO PHARMACOLOGY AND TUMOR MODELS

We are currently seeking a highly motivated candidate with a strong background in cancer immunotherapy to join our pharmacology team. The successful candidate should be experienced in preclinical pharmacology research and be able to oversee daily research activities at both scientific and technical levels. In this role the candidate will be reporting to Sr. Director, Pharmacology. 

Key responsibilities:

• Coordinate team efforts to develop animal models, preclinical data and reports using internal and external resources to support the development of the research pipeline, including representation of the function in Program Team settings
• Work closely with multiple functional groups to progress immune-cell-based cancer therapies to the clinic.
• Oversee daily activities to conduct in vivo, ex vivo and in vitro experiments for evaluating Adicet’s immune cell platforms.
• Manage and direct daily work of junior research staff at both scientific and technical levels. Perform hands-on work when needed.
• Support relevant activities such as biomarker discovery and translational studies for Adicet’s clinical candidates. Oversee CRO activities when needed to support additional nonclinical or efficacy assessments.
• Participate in scientific discussions and conception of new research approaches. Contribute intellectually to the research goals. 
• Prepare data presentations for internal and external meetings, regulatory filing and publications.  

Qualifications:

• PhD in Immunology or relevant biological sciences with a strong immuno-oncology research background, ideally in immune cell therapy field.
• A minimal eight years of research experience with a minimal four years of drug development experience in an industry setting.  
• Expertise in preclinical murine tumor models including xenograft, PDX, and/or syngeneic models and experience in various in vitro cell based assays are required. Hands-on experience in in vivo bioluminescence and/or fluorescence imaging workflow and data analysis is preferred.
• Previous hands-on experience in multi-color flow cytometry and proficient data analysis is a must. 
• Working knowledge of immunohistochemistry and data interpretation is a plus.
• Demonstrate scientific creativity, critical thinking, and analytical problem-solving skills, with a strong track record of research productivity as evidenced by first author publications.
• Ability to work efficiently and independently under minimal supervision with strong organizational and record keeping skills. 
• Previous management experience is required.
• Excellent written and verbal communication skills.    

Benefits:

Adicet Bio offers both comprehensive benefits and Paid Time (PTO) plans for employees, which begin on the first day of employment, as well as the opportunity to work in a growing, dynamic environment.

Adicet Bio is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.