Computational Biologist

About the role

The Computational Biologist will work closely with scientists and computational biologists to analyze NGS genomics data and develop bioinformatics methods to solve exciting and challenging problems in cell and gene therapy, immunology, and stem cell biology. You will develop workflow from FASTQ to variant calling and annotation to analyze somatic and germline variants in human genomes. You should be able to partner effectively with the Analytical Genomics team to design appropriate studies and analyze genomics data, and the Computational Engineering team to refactor and automate analysis pipelines as appropriate. You should be a team player and fantastic at cross-functional communication. The ability to be flexible, to learn from and teach others genetics & genomics, and to work in a highly collaborative environment will be critical to success. This position reports to the Principal Scientist, Computational Biology.

What you'll do

• Develop analysis workflows from existing tools or modify existing methods to analyze NGS data, such as WES/WGS, targeted sequencing and bulk RNA sequencing. This includes development of novel Bioinformatics methods as needed to answer platform and biological questions to meet company objectives. Demonstrate validity of methods through prototypes and benchmarking using appropriate controls
• Develop and implement study designs to benchmark analysis workflows
• Work with other computational biologists and computational engineers to deliver production pipelines
• Partner with groups in Cell Therapy, Cell Engineering, and Technical Operations to design studies, recommend appropriate assays, and analyze and interpret data from WGS/WES, aCGH, targeted oncogene panels, RNA sequencing and epigenomic sequencing.
• Proper documentation of code, workflows, and analyses including study reports for nonclinical and clinical studies and regulatory filings
• Communicate to a broad audience with a range of technical, analytical, and biological expertise and present results on a regular basis at various group meetings

What we're looking for

• PhD in computational biology, genetics, bioinformatics, statistics, or related scientific discipline and up to 2+ yrs academic or industry experience. BA and/or MS plus 7+ yrs or equivalent combination of education and work experience
• Strong scientific background including an understanding of molecular biology and genomics
• Hands-on experience with all steps for the analysis of WGS/WES data and/or targeted panels
• Demonstrated proficiency in Python and/or R
• Routine use of version control such as git
• Experience with high performance computing and proficiency in *ix
• Demonstrated strong analytical skills and problem-solving
• Must be detail oriented, self-motivated, flexible, and able to prioritize and manage several fast-paced projects concurrently
• Outstanding verbal and written communication skills for technical and non-technical audiences
• The candidate should be collaborative, a team player and demonstrate curiosity
• Ability to engage in crucial conversations - providing and receiving feedback

What will separate you from the crowd

• Experience with AWS or similar cloud computing platforms
• Familiarity with workflow languages such as Nextflow
• Experience with variant calling low frequency somatic mutations
• Experience with product development and/or Regulatory filings a plus

What you should know

• Working safely on a predictable and regular basis is an essential job function for this position and the Company requires that all individuals, subject to certain exceptions, be fully vaccinated against COVID-19

How we work together

• Lead from every seat - we seek to understand, act with honesty, and engage in the crucial conversations
• Thrive as a team - we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
• Make it happen - we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.