Scientist I, In vitro Neurobiology Research

Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. For more information, please visit www.Encoded.com.

Encoded Therapeutics is seeking a highly motivated Scientist I – in vitro neurobiology research, to join our Molecular and Cellular Pharmacology group. This individual will work closely with other members of the group to develop and execute on primary neuron culture based assays to support program advancement from target identification to preclinical proof-of-concept. The successful candidate will primarily conduct in vitro studies using a wide range of biological tools and methods, and is expected to have strong experience with primary neuron culture from rodent brain and relevant experimental methods in neurobiology.

Responsibilities:

• Collaborate with the program research team, provide technical experience, and design/execute/interpret rigorous in vitro studies using primary neuron culture
• Design and perform molecular biology, biochemistry and/or electrophysiology assays, with a focus on in vitro primary neuron analysis. Select and run appropriate statistical tests.
• Facilitate the development of a core to optimize and perform in vitro preclinical assays using primary neuronal culture.
• Review relevant scientific literature and identify new/alternative approaches to address critical research questions or support the development of new techniques.
• Manage external relationships with CROs when required.
• Follow company guidelines and document experimental procedures and results in detail.
• Present findings to interdisciplinary scientific teams to seek input on key studies and propose data-driven GO/NO GO decisions.

• PhD in neuroscience or molecular biology with demonstrated technical proficiency related to hippocampal or cortical neuronal culture.
• Strong background in molecular biology techniques.
• Willingness to perform tissue dissections.
• Experience with IPSC-derived neurons as well as use of MEA for electrophysiological characterization of primary or IPSC-derived neurons is highly beneficial.
• Ability to independently formulate a study plan based on overall project goals, and carry out a series of studies from start to finish
• Excellent oral and written communication skills .
• Collaborative mindset and a willingness to provide mentorship to junior RAs and scientists
• Thrives in a dynamic and fast-paced research environment

• Comprehensive benefits package, including competitive employer premium contributions
• Meaningful stock option grants
• PTO, sick time and holiday pay
• Generous Parental Leave program
• Pre-tax medical and dependent care programs
• STD, LTD, Life and AD&D
• Professional development opportunities
• Team-building events
• Fully stocked kitchen
• Purple Tie dry cleaning service
• Fitness center

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.

If you need assistance or an accommodation due to a disability, you may call us at +1 650-491-0272.

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