Associate Scientist I
MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 300+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer as well as various autoimmune disorders and infectious diseases. Our products and platforms have attracted multiple partnerships with leading pharmaceutical companies around the globe.
The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.
Summary of Position
The Associate Scientist I position conducts in vivo research and supports the operation of the vivarium. The primary responsibility of the position will be to independently execute all aspects of tumor model development, pharmacokinetic/pharmacodynamic and efficacy studies in mice. Additional responsibilities will include conducting laboratory research outside of the vivarium.
Responsibilities and Job Duties
- Participates in the planning and design of in vivo studies.
- Independently executes tumor model development, pharmacokinetic and efficacy studies with high reproducibility and attention to detail. Responsible for implantation of tumor cells, administration of study compounds, data collection (tumor size and body weight measurements), health monitoring, tissue collection, and study report authoring and presentation of data internally.
- Executes a range of laboratory experiments efficiently, and with high reproducibility, including sample preparation, mammalian cell culture and in vitro bioassays in support of research projects.
- Makes detailed study observations, collects and analyzes data, interprets results, and presents results at internal research meetings.
- Engages in problem solving and the identification and development of new methodologies to improve efficiencies and expand capabilities.
- Performs minor surgical or technical procedures, including but not limited to, tumor and organ resection, collection of urine and blood for biochemical and molecular analysis, immunizations, and necropsies.
- Prepares tissues and delivers to collaborators for downstream research studies.
- Procurement of animals and supplies, maintenance of the facility and equipment, conducts animal husbandry and daily animal health checks.
Education & Other Credentials
- Bachelor’s degree in a scientific discipline with minimum of five years of related animal modeling experience
- Master’s degree in a scientific discipline with a minimum of two years of related animal modeling experience
- Minimum of two years of related animal modeling experience required.
Knowledge, Skills and Abilities
- Ability to work independently, with minimal supervision.
- Experience and technical proficiency in handling rodents including restraining, identifying mice, tumor measurements via calipers, administering test articles and medications (intravenous, intraperitoneal, and orally), performing blood collection, tumor and organ resection, necropsy, and euthanasia.
- Experience with immunodeficient mice and genetically engineered mouse models.
- Capacity to work in a team and communicate with management in a fast-paced research environment.
- Ability to keep detailed and accurate notebooks and computer records and maintain/update data in computer-based applications/databases (Microsoft applications, Prism, Study Director).
- Demonstrated strong written and oral communication skills, and ability to present results in a group setting.
- Problem solving skills, attention to detail, ability to use good judgment.
- Knowledge of Standard Operating Procedures for animal facilities and the basic requirements for maintaining laboratory animals according to IACUC approved protocols.
- AALAS ALAT/LAT certification.
- Experience with the Study Director software application.
- Experience with aseptic mammalian cell culture, molecular biology and biochemistry techniques.
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