Research Associate II, Preclinical Science

About Ambrx:
Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein
therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the
company to genetically engineer proteins with new amino acid building blocks beyond the common
twenty, enabling the biosynthesis of proteins with new physical, chemical and pharmacological
properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a
breakthrough technology to create the next generation of protein-based medicines.

KEY RESPONSIBILITIES
• Independently design and perform in vitro binding and cellular assays to assess drug
candidate cytotoxic and/or immunomodulatory effects
• Analyze and interpret experimental results and present findings at project team meetings
• Provide technical expertise to project teams for functional assay development,
immunoassay design, flow cytometry, and/or other specialized techniques
• May support management of external studies with CROs and/or collaborators
• Maintain detailed records in laboratory notebooks in accordance with company policy
• Contribute to writing of technical reports, SOPs, patent applications, and scientific
manuscripts for publication

PROFESSIONAL EXPERIENCE/QUALIFICATIONS
• B.S. in Biology/Biochem or similar + 6 years industry experience; or M.S. + 4 years industry
experience
• Consistent track record of rigorous in vitro agonist/antagonist study design, including
appropriate controls, benchmarks, dose responses, variability, reproducibility, etc.
• Deep experience performing in vitro functional assays using cell lines and primary human
immune cells (e.g. cytotoxicity, immune-tumor cell co-culture, immune activation)
• Independent proficiency in diverse laboratory techniques, including cell culture, flow
cytometry, ELISA/MSD/HTRF/etc, and primary human immune cell isolation
• Demonstrated ability to analyze complex data sets and concisely and communicate results
• Excellent organizational, time-management, and multi-tasking skills
• Consistently uses analytical thinking, persistence, and creativity to overcome challenges
• Demonstrated ability to deliver decision-making data sets within a matrixed organization
• Excellent verbal and written communication and interpersonal skills

How to Apply
To be considered as an applicant, please submit your resume/CV referencing the specific position of
interest and position code. Applicants whose qualifications and experience most
closely match the position requirements will be contacted for further evaluation. Ambrx offers
competitive compensation & benefits. EOE