Research Associate
- Employer
- BioMarin Pharmaceutical Inc.
- Location
- Novato, California
- Start date
- Aug 28, 2021
View more
- Discipline
- Regulatory, Research/Documentation, Science/R&D, Research
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay, Best Places to Work
Job Details
BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.
SUMMARY
The Research Associate is involved with the design of protein purification processes suitable for manufacturing therapeutic proteins or gene therapy vectors, and with the transfer of those processes to manufacturing facilities. The Associate works primarily in the laboratory to design, carry out, and analyze experiments that lead to the design of effective processes.
RESPONSIBILITIES
The applicant must exercise technical discretion in the design and execution of varied experiments and projects. He or she provides quantitative analysis of data and interpretation of results, writes protocols, and contributes to technical reports. At times, he or she may evaluate complex methods, technologies, or laboratory equipment. He or she may adapt existing processes and develop new processes.
The applicant may provide assistance to manufacturing start-up, troubleshooting, and validation. Will be expected to contribute to scientific publications and regulatory submissions, and attend external seminars.
More specifically, this position requires the following roles. The primary focus is laboratory experimental work:
- Execute small-scale experiments to design, optimize, and characterize purification processes.
- Perform experiments to determine operational ranges and robustness for various steps in purification processes.
- Develop, perform and troubleshoot analytical assays required to support experiments (e.g., UV absorbance, SDS-PAGE, western blot, HPLC, enzyme activity, and ELISA).
- Assist with process scale-up and transfer into the clinical manufacturing plant.
- Order materials for the laboratory and maintain equipment and facility through targeted preventive maintenance.
- Use pilot-scale equipment to process cell-culture harvests and to prepare purified proteins for animal studies or research.
EXPERIENCE
Required Skills:
- Solid experimental design and troubleshooting skills
- Broad technical proficiency in protein purification and analysis allowing effective execution of experiments
- Able to use computers effectively for data analysis and presentation
- Excellent communication skills, including scientific writing
- Ability to mentor others and gain acceptance of ideas
Desired Skills:
- 1+ years industry experience in purification process development
- Expertise in protein chromatography, ultrafiltration, HPLC, and spectrophotometry
- Expertise in viral vector purification
EDUCATION
Minimum: Four-year Bachelor’s degree in chemical engineering, biological engineering, biochemistry, chemistry, or biological sciences
Preferred: Bachelor’s degree in the above scientific disciplines with 1-3+ years experience in purification process development; or a Master’s degree with 0-3+ years experience.
PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated.
Company
BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.
Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.
Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.
- Website
- https://www.biomarin.com/
- Location
-
California
United States
Get job alerts
Create a job alert and receive personalized job recommendations straight to your inbox.
Create alert