Scientist, Biochemistry and Quantitative Pharmacology-Enzymology (non-PhD)
- Employer
- Pfizer
- Location
- La Jolla, California
- Start date
- Aug 26, 2021
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- Discipline
- Science/R&D, Biotechnology, Pharmacology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Beach, Best Places to Work
Pfizer’s purpose is to deliver breakthroughs that improve patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.
What You Will Achieve
The Oncology Research Division in La Jolla, California is seeking a motivated and innovative Scientist (BS/MS level) to join the Biochemistry and Quantitative Pharmacology—Enzymology group within Discovery Technologies. The successful candidate will provide their expertise in mechanistic biochemistry/enzymology to enable the advancement of pre-clinical programs within the Pfizer Oncology portfolio. They will gain in-depth, hands-on experience with cutting-edge drug discovery strategies from concept to clinical candidate nomination on diverse targets ranging from kinases, non-kinase enzymes, and other challenging proteins relevant to cancer.
How You Will Achieve It
- Conduct high-quality, properly controlled experiments with an emphasis on rigor and reproducibility
- Perform mechanistic analyses of key project compounds
- Identify and execute innovative screening strategies using internal and external knowledge
- Develop, optimize, and validate robust plate-based biochemical assays suitable for screening and SAR
- Collaborate within the group and across project teams to enable the identification and advancement of promising drug candidates to the clinic
- Participate and present results at project meetings and other internal, external meetings
- Communicate results precisely in both written and oral formats
Qualifications
Must-Have
- Bachelor of Science degree in Biochemistry or related discipline with 6+ years relevant post-graduate experience or MS degree with 4+ years of experience
- Experience in biochemistry, including enzyme kinetics and protein-ligand interactions
- Documented experience in biochemical assay development, providing SAR support
- Experience with data analyses and management
- Excellent organizational skills with outstanding verbal and written communication
- Ability to plan, execute, and interpret experiments
- Ability and desire to effectively collaborate within a matrixed and diverse environment
- Strong self-motivation, can work independently and within a team
- Positive and enthusiastic attitude with the desire to help others
- Interest in expanding their own scientific knowledge and skills
Nice-to-Have
- Strong interest in evaluating and implementing new technologies
- Experience developing high throughput biophysical and/or cellular protein-ligand assays
- Experience and/or interest in using high throughput mass spectrometry for SAR
- Scientific knowledge on a specific area of emphasis for Pfizer Oncology (e.g., Cell Cycle, Cancer Immunology, etc.)
PHYSICAL/MENTAL REQUIREMENTS
- Ability to execute laboratory experiments and perform complex data analyses
- Ability to interpret results relative to published data and ongoing Pfizer programs
- Strong interpersonal skills and a desire to succeed in a team setting
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