Scientist, Translational Science

South San Francisco, CA
Aug 03, 2021
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Graphite Bio is a clinical-stage biotechnology company focused on harnessing the power of targeted DNA integration. Graphite Bio uses next-generation CRISPR based technology platforms for developing curative gene correction-based stem cell therapies for serious and life-threatening genetic diseases with inadequate existing treatment options

The Role:
We are seeking a talented Scientist, Translational Science, to drive biological research and development activities for our translational pipeline based on gene correction in hematopoietic stem cells.
What You WIll Do:
  • Drive the preclinical pipeline development of ex vivo programs based on targeted integration in blood stem cells (e.g. hematopoietic stem cells) for diseases of the blood and immune system.
  • Bring preclinical pipeline programs all the way from discovery to preclinical proof-of-concept to IND-enabling studies.
  • Design, execute and interpret data for targeted integration experiments in human cell lines, human primary cells, human stem cells, as well as in vivo engraftment studies in NSG mice.
  • Possibility to manage team including Research Associates.
  • Provide guidance, lead biology, and CRISPR science activities in research and development areas, with a special focus on meeting regulatory requirements and improving the company’s existing technology platforms. 
  • Draw appropriate conclusions effectively, and Communicate scientific data internally and externally. Ensure high-quality departmental documents for regulatory submissions, manuscripts, abstracts and publications. 
  • Support preclinical studies through oversight of interaction with contract research organizations and contribute to relevant data analyses. 
  • Work with corporate legal to file intellectual property on novel and inventive discoveries.
  • Assist business development in assessing in and out-licensing opportunities. 
  • Develop strategies to ensure effective achievement of broader company scientific objectives.
  • Establish & contribute positivity to the broader vision of company culture

What You WIll Bring:
  • Ph.D. in neuroscience, immunology, molecular biology, stem cell biology, and/or genetics preferred. Senior Research Associates with a strong track record of independent research also welcome.
  • Work experience in biotech, pharmaceutical industry, and/or academic postdoctoral research and development settings preferred.
  • Background in neuroscience and brain anatomy and/or blood-brain barrier immunology preferred. 
  • Strong publication record demonstrating significant contributions in the field. 
  • Excellent communication, organization, interpersonal, and scientific writing skills.
  • Ability to demonstrate effective leadership in fast-paced and highly dynamic situations.
  • Proven ability to positively impact company culture and demonstrate flexibility in a fast-paced environment.

Fit with Graphite Bio’s culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise
Ability to function at a high level in a team setting whether leading the group or acting as an individual
Values-based leadership consistent with Graphite Bios’ Core Values
Excitement about the vision and mission of Graphite Bio 

Compensation/ Benefits:
Competitive salary with equity 
Health benefits

Graphite Bio is an equal opportunity employer, and all qualified applicants will receive consideration for
employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national
origin, protected veteran status, or disability status, or any other characteristic protected by law.