Scientist – Protein Chemistry

San Diego, CA
Aug 03, 2021
Required Education
Masters Degree/MBA
Position Type
Full time

Tentarix Biotherapeutics is an exciting company with a game-changing technology platform that allows for the discovery of next generation, multi-specific investigational drugs to address the key limitations of existing cancer, autoimmune, and other disease therapies. 

We are led by a seasoned executive team with proven expertise in the field of multi-specific drug discovery. We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape. 

Tentarix team members are creative, hands-on, self-directed, and display excellent communication skills. They also exhibit a high level of integrity, resiliency, and a determination to contribute to the success of the company. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our individuals and collectively.



In this vital role you will be responsible for the production, assessment, and optimization of multi-specific therapeutic drug candidates, with many of the molecules of interest being complex biologics. 


  • The Protein Chemistry group is primarily responsible for the purification and analytical assessment of novel and complex scaffold molecules, often antibody-based, that will be the next generation of multi-specific molecules therapeutics.
  • Be a part of a multidisciplinary team with capabilities in protein engineering, purification, and characterization of large molecule drug candidates with a heavy focus on purification and characterization.
  • The candidate should be capable of being a scientific leader with the ability to drive innovation, lead projects and teams, solve complex technical problems, and work independently as well as in cross-functional teams.
  • The individual should also be innovative in developing methodologies that enhance protein chemistry capabilities, reduce cycle time, increase throughput, and improve the quality of our lead molecules.
  • The Scientist should be able to interpret and report scientific results that support the generation of publications, patents, or regulatory submissions, and participate in internal and external scientific meetings.
  • Good written and oral presentation skills are a must.
  • Ph.D., post-doctoral experience, and/or Masters degree with +8 years in industry producing and characterizing protein therapeutics
  • Ability to multi-task and work flexibly with a high sense of urgency in a cross-functional highly matrixed team environment
  • Deep expertise in purification of complex engineered molecules using AKTA Pure and Avant systems
  • Expertise in advanced protein characterization and analytical techniques including analytical HPLC using multiple modalities, mass spec, binding kinetics, epitope binning, thermal stability, polyreactivity, and self-interaction
  • Knowledge in high throughput purification of large panels of engineered biologic molecules
  • Ability to multi-task and work flexibly with a high sense of urgency in a cross-functional team environment
  • Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation
  • Strong communication and interpersonal skills. 

Qualifications and Skills: 

Our employees are the Company’s most valuable asset, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. 

Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.