Senior Scientist, Directed Evolution

South San Francisco, CA, United States
Aug 03, 2021
Required Education
Bachelors Degree
Position Type
Full time

Sana Biotechnology is developing advanced delivery and genome engineering capabilities to enable the next generation of gene and cell therapies. We seek a highly motivated and creative Senior Scientist to join our new Genome Editing Technologies group. The level of this position will be commensurate with experience and skill. The successful candidate will work with colleagues to establish novel technologies for genome targeting and cellular engineering that will directly impact the scope and power of our therapeutic programs. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of genome editing research.

  • Work with the team to establish genome targeting platform capabilities
  • Establish and develop new gene editing and gene regulation technologies
  • Coordinate with cross-functional teams to expand the range and sophistication of engineerable behaviors that can be applied to our cell therapy programs
  • Communicate and document findings via verbal and written methods


Required Qualifications
  • PhD in scientific discipline w 5+ yrs experience in academic research and/or industry. BA or MS plus 8+ yrs or equivalent combination of education and work experience; Deep subject matter expertise and an emerging leader.
  • Strong publication record demonstrating proficiency in directed evolution
  • Exceptionally strong molecular biology skills
  • Demonstrated ability to synthesize and select high-complexity combinatorial libraries
  • Ability to use available structural information to inform library design
  • A working knowledge of the energetics and kinetics of recognition processes
  • Ability motivate and frame new directions in protein design for genome engineering, and reduce strategic initiatives to an actionable plan
  • Excellent communication skills; ability to present effectively to teams with diverse backgrounds
  • Ability to adapt to increasing scope and complexity of work as projects mature
  • Comfortable in a fast-paced research environment with minimal direction, and able to adjust workload based upon changing priorities
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Facility with one or more programming languages such as Python
  • Demonstrated high throughput and multiplexing capabilities
  • Ability to process and analyze large data sets
  • Familiarity with methods and concepts used to characterize the specificity of site-specific DNA-binding proteins
  • Familiarity with an affinity selection method such as phage display
  • Tissue culture skills
  • Experience with sequence analysis for characterization of gene editing outcomes

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.