AbbVie

Biological Research Scientist - Protein Science

Employer
AbbVie
Location
Irvine, California
Posted
Jul 31, 2021
Ref
2112732
Required Education
Associate Degree
Position Type
Full time
About Allergan Aesthetics
At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products. Our aesthetics portfolio includes facial injectables, body contouring, plastics, skin care, and more. Our goal is to consistently provide our customers with innovation, education, exceptional service, and a commitment to excellence, all with a personal touch. For more information, visit www.AllerganAesthetics.com.

Allergan Aesthetics R&D, Biological Research is seeking a highly motivated and innovative candidate for the role of Research Scientist, Protein Science. The successful candidate for this position will work independently and contribute expertise to projects aimed at generating protein-based therapeutics in a discovery research environment. He/she will perform molecular biology techniques (e.g., PCR, site-directed mutagenesis, restriction enzyme-based cloning, ligase independent cloning (LIC)) to support the group’s protein engineering efforts.  He/she will implement a variety of chromatography strategies (IMAC, IEX, SEC, HIC) to purify proteins with or without affinity tags.  The candidate will utilize SDS-PAGE, Western blot, and ELISA to evaluate target proteins during and following purification. This individual will organize, analyze and interpret results, and make project recommendations. The individual will also communicate and present their projects and results in team meetings and reports. The ideal candidate will be required to propose, design and execute cloning and purification strategies  while demonstrating exceptional troubleshooting skills.  Additional experience with protein/enzyme characterization including DLS/aggregation, HPLC (reverse phase/ size exclusion) and enzyme assays is beneficial, but not required.   

The successful candidate will collaborate extensively with other Research Scientists and Associates, while taking personal responsibility for the success of assigned tasks and projects.  Experimental design will be guided in consultation with management, but the candidate is expected to independently conduct and develop modified or new techniques for conducting experiments. 

Responsibilities:

  • Independently conduct experiments of moderate complexity, designing the work plan so that reliable results are achieved in a timely manner.
  • Plan experimental approaches with minor supervisory guidance.  Discuss, recommend, and modify experimental techniques as needed.
  • Document and interpret results in order to reach conclusions, discuss with supervisor and decide on subsequent experiments.
  • Management of laboratory supplies and equipment needed for research (ordering supplies, equipment maintenance, record keeping, and inventory)
  • Prepare technical reports, presentations, and appropriate documentation of work performed.  Assist supervisor in maintaining project documentation.
  • Develop and maintain up-to-date knowledge and skill base by reviewing the literature, attending seminars and meetings
  • Attend and participate in lab, team and departmental meetings.  Present data as required.

Qualifications
  • PhD with 0-4 years’ experience in Molecular Biology, Biochemistry or related discipline with a focus in molecular cloning, heterologous protein expression, protein purification and characterization.  Individuals with a MS degree and 5 or more years of applied experience or individuals with a BS degree and 7 or more years of experience may also qualify.
  • Proven experience in molecular biology techniques (PCR, seamless cloning, restriction enzyme-based cloning, primer design)
  • Hands-on experience with DNA sequencing (Applied Biosystems Genetic Analyzer 3500)
  • Skilled in sequence design and analysis software (e.g., BLAST, SnapGene, Geneious Prime)
  • Hands-on experience with AKTA FPLC purification systems
  • Experience with protein/enzyme characterization including SDS-PAGE, western blots, ELISAs
  • Exhibits flexibility and a commitment to scientific excellence.
  • Highly motivated, hands-on experimentalist who thrives in a collaborative, multidisciplinary environment.
  • Able to have a direct impact on project performance.
  • Possess strong interpersonal skills with an ability for creative thinking.
  • Independently perform experiments and interact in a team environment.
  • Meticulous attention to detail and diligence in record keeping. 

Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.