Principal Scientist, Protein Interactions
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Protein Interactions Group is seeking a skilled and enthusiastic Senior Scientist to support our biophysical characterization of unpurified and purified antibody candidates by providing quantitative data that drive decisions in a highly collaborative environment. The candidate will report to the Protein Interactions Group lead to help discover novel therapeutic antibodies. This high-level scientific position is laboratory focused. You will represent the Protein Interactions Group at discovery team meetings for a variety of oncology projects, where you contribute with your biophysical expertise to selecting and optimizing therapeutic antibodies.
The Protein Interactions Group is seeking a skilled and enthusiastic Principal Scientist to support our biophysical characterization of drug candidates by providing quantitative data and deep biophysical understanding to drive decisions in a highly collaborative environment. The candidate will report to the team lead to help discover novel therapeutic antibodies. This high-level scientific position is laboratory focused. You will represent the Protein Interactions Group at discovery team meetings for a variety of oncology projects, where you contribute with your biophysical expertise to selecting and optimizing therapeutic antibodies.
The primary responsibility of the role is to support our biophysical characterization of unpurified and purified antibody candidates. Responsibilities include:
1) Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using surface plasmon resonance (SPR) and kinetic exclusion assays (KinExA) with sufficient rigor to both evaluate and characterize the antigen-antibody interactions under study.
2) Perform epitope binning studies using SPR.
3) Drive the development of novel biophysical assays.
4) Contribute as an essential and reliable component to help the Protein Interactions Group “drive” projects to a successful conclusion with a high level of motivation.
5) Interact productively with scientifically diverse research teams, including clear and concise presentation of data through oral presentations and written reports/communications.
6) Uses professional concepts to contribute to development of company’s concepts and principals to achieve objectives in creative and effective ways.
Position requires a background in Biophysics, Chemistry, Biochemistry or related field with a Ph.D. and 5 or more years of professional experience, or a master’s degree with 10 years or greater of relevant experience in a pharmaceutical or biotechnology research environment.
-Knowledge of surface plasmon resonance and experience with the operation of diverse SPR instrumentation
-Knowledge of KinExA experiments and experience with the operation of KinExA instrumentation
-Demonstrated ability to interpret biophysical binding data
-Demonstrated ability to communicate and present biophysical binding data to scientifically diverse teams
-Demonstrated ability to creatively solve problems related to biophysical experimental design
-Knowledge and understanding of the application of statistical principles and statistical software (e.g. GraphPad) required
-Must be highly self-motivated, detail-oriented and well organized.
-Has the ability and desire to work in a team-oriented environment.
-Experience with flow cytometry, including a background in flow cytometric antibody binding screens not required but a plus
-Experience with Octet BLI instrumentation a plus
-Crystallography experience a plus
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
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