Scientist (non-PhD), T Cell Biology
The Cancer Immunology Discovery group at Pfizer is seeking a highly motivated and creative Scientist to join the T cell activation and PDx resistance team to identify and evaluate novel therapies in the fields of Cancer Immunotherapy. The successful candidate will have expertise in T/NK cell biology, the tumor microenvironment, target validation and a track record of success in immune-oncology drug discovery. The candidate will work in a fast-paced and highly collaborative environment. S/He is expected to conduct bench work, keep up with relevant research field, and move drug development via interactions with cross-function groups.
- Discover and develop new therapeutic modalities for cancer immunotherapy targeting T cells or NK cells.
- Design and execute in vitro cell line or primary cell based experiments and optimize the assays for antibody drug candidate screening.
- Execute mechanistic, PD, and biomarker studies for preclinical-stage therapies using in vivo mouse models and ex vivo assays, including but not limited to multi-parameter flow cytometry, target expression analysis and functional assays.
- Collaborate with protein engineering, translational pharmacology, PK/PD, toxicology, computational biology, and clinical development group to pursue the most promising drug candidates.
- Participate and present in internal and external project meetings as well as at site and cross-site meetings.
- Record experimental protocols/results in detail and write technical reports for regulatory filings.
- BS/BA with 5+ years of experience or MS with 3+ years of experience.
- Experience in development of antibodies/bispecifics targeting T cells or NK cells.
- Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, and/or proliferation by using T cells or NK cells).
- Experience with flow cytometry (Fortessa and/or Cytek Aurora), ELISA, MSD, reporter assays or cytotoxic assays (CTG and/or LDH assays).
- Ability to plan and execute in vitro experiments with minimal supervision.
- Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.
- Previous industrial experience and knowledge of drug discovery.
- Proficiency in high-parameter immune phenotyping of immune cells (isolated from mouse and/or human tissues) by Flow Cytometry (comfortable running at least 10-color panels, including intracellular staining).
- Experience in assessing T cell and/or NK cell function, differentiation, and memory development.
- Experience with various murine tumor and/or infectious disease models.
- Standing, sitting, bending, lifting, walking in a laboratory setting.
- Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory.
- Standard business office conditions; sitting, standing as appropriate.
Other Job Details
- Eligible for Employee Referral Bonus