Head of Cardio/Metabolism Discovery Research
Within the Internal Medicine Research Unit (IMRU), one of the key strategic focus areas is identifying novel therapies to improve metabolic health in patients suffering from a range of metabolic diseases, including heart failure that is associated with diabetes or the metabolic syndrome. As a key member of the cardiometabolism discovery biology team, this individual will be responsible for formulating and implementing therapeutic strategy as well as leading discovery projects from ideation to early clinical development. He/she will play a key role in creating and driving a data-driven research strategy for cardiometabolism, which includes identification and validation of targets for drug discovery and disease/target related biomarker. Substantial knowledge and experience in basic cardiovascular biology and the pathophysiology of heart failure are essential, as is evidence of substantive accomplishments in the areas of metabolic and/or cardiovascular disease. In addition, the individual will build and facilitate collaborations with partners in the scientific community, as well as within the Pfizer network. He/she will have daily interactions with and supervision of a team of creative and innovative scientists in a supportive environment to conduct rigorous scientific and drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to lead and work as part of a team are essential qualities of the role.
Successful candidates will be expected to:
Apply scientific and clinical expertise to the identification and validation of new drug candidates in the area of metabolic heart disease.
Contributing to the more general RU strategy by intellectual contributions.
Maintain a ‘cutting edge’ awareness of scientific and technical developments, human genetics, preclinical to clinical translation and apply these where possible to advance the portfolio programs.
Design and conduct studies to increase confidence in human biology for new approaches and targets; provide strong scientific leadership and experimental guidance from target generation-to-clinical candidate programs.to a team of scientists with diverse in vitro, ex vivo and in vivo biological expertise.
Partner effectively with multi-functional teams encompassing research (including Integrated Biology team and Chemistry) and development (including early clinical development group)
Actively contribute to the external collaborative scientific strategy, e.g., identify and build collaborations and liaise with external scientists.
Create an environment that values innovation, leadership, employee development, scientific excellence, urgency and accountability.
Present research findings to the scientific community through consistent publication in peer-reviewed journals and presentation of the results at scientific meetings.
Ensure that all research/discovery work is conducted with highest quality and in accordance with relevant regulatory, QC, and compliance guidelines.
Provide mentorship to more junior colleagues.
Advise leadership on issues of relative value and prioritization of ongoing programs.
Actively explore opportunities for novel investments through partnerships with the outside biotech community and new scientific initiative internally.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
PhD, MD/PhD or MD with a minimum of 10-15 yrs research experience leading a research laboratory in academic or industry setting, with a sophisticated understanding of modern cardiovascular disease pathophysiology and underlying biology.
A demonstrable record of applying the highest scientific rigor and ethical standards to the conduct of biomedical research.
Experience leading or collaborating closely with a clinical group that carries out translation research or drug development studies.
Demonstrated excellence in designing, executing and interpreting studies of cardiovascular disease biomarkers in nonclinical studies that enable their validation for clinical application.
Demonstrated ability to think strategically and creatively while contributing to multiple projects, thrive in a highly collaborative, multi-disciplinary team setting. Strong written/verbal communication skills and ability to effectively collaborate with scientists working in other disciplines are essential.
A demonstrated record of scientific achievement, for example through high quality and impactful publications in leading scientific and/or ,medical journals.
Evidence for prior success in colleague mentoring and career development
Drug discovery experience is preferred but not essential.
Other Job Details:
Eligible for Relocation Package
Eligible for Employee Referral Bonus