Scientist, Therapeutic Genome Editing

Location
Brisbane, CA, United States
Posted
Jul 30, 2021
Ref
1457999848
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
COMPANY

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences is advancing disease detection and treatment using its novel CRISPR systems that can deliver on the promise of precision medicine across diagnostics and therapeutics. Furthermore, Mammoth's CRISPR technology platform will enable new solutions in life science research, healthcare, agriculture, biodefense and more.

Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.

TEAM

Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.

OPPORTUNITY

Mammoth is seeking a Scientist with expertise in therapeutic genome editing. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in primary cells and disease models. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals.

KEY RESPONSIBILITIES
    • Initiate, direct, and perform experiments to evaluate novel genome editing systems
    • Advance the application of novel CRISPR systems for human therapeutics
    • Manage direct reports and collaborate with others on the team
    • Record, document, analyze and communicate scientific data to senior staff and team members and participate in the writing of SOPs, report, and manuscripts for publications


REQUIRED QUALIFICATIONS
    • Ph.D. in relevant field with 3+ years relevant experience
    • Strong background in molecular biology, cell engineering, gene and cell therapy
    • Experience with genome editing for human therapeutics
    • Experience with viral and/or non-viral delivery methods (such as AAV and LNP)


PREFERRED QUALIFICATIONS
    • Demonstrated expertise with CRISPR for human therapeutics
    • Experience with characterization and optimization of CRISPR systems
    • Experience working with primary cells, iPSC and complex cell culture systems
    • Experience with AAV vector optimization and production
    • Experience with NGS to characterize CRISPR editing efficiency and specificity
    • Strong communication, presentation and data analysis skill


BENEFITS
    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching


It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.