Senior Associate Scientist, Gene Therapy (Rare Cardio)
Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.What You Will Achieve
Pfizer’s Rare Disease Research Unit (RDRU) is focused on developing therapies for rare inherited diseases, including rare muscle, cardiac, and neurological disorders. We are looking for a Senior Associate Scientist at the BS or MS level who will be a member of the rare cardiac disease research team and will be focused on the progression of therapies to treat these life-threatening diseases. The candidate will be a dedicated and committed experimentalist, applying creativity and rigor to the drug discovery process. The candidate will have extensive experience with in vitro and cell & molecular biology techniques, as well as basic in vivo techniques needed to support rodent research. Experience with cardiac myocyte cell culture and in vivo techniques applied to cardiovascular biology a plus, though not required. The candidate is expected to have excellent problem solving, critical thinking, record keeping and presentation skills (written and oral) and will need to effectively communicate with internal and external partners.How You Will Achieve It
- Support the design and conduction of experiments to advance the development of candidate therapies for rare cardiac diseases.
- Perform experimental studies, carry out data analysis and interpretation, record results in an electronic lab notebook, and stay abreast of novel relevant findings from the literature.
- Interface with internal interdisciplinary teams.
- Work collaboratively as part of the Rare Disease Discovery biology group to advance the overall pipeline of therapies.
- BS or MS with 3+ years of experience in cellular biology, molecular biology, physiology, or a related discipline.
- Experience with modern in vitro biochemistry and molecular biology techniques for protein and RNA characterization and genetic manipulation with RNAi and CRISPR
- Experience with standard primary cell and cell line culture techniques.
- Experience supporting a multidisciplinary project team including the ability to generate high quality data in a time-sensitive environment, to assimilate new information from multiple sources, and to effectively communicate with internal scientists.
- Creativity, self-motivation and the ability to work independently, including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.
- Thorough and detailed experimental record keeping essential.
- Experience with any cardiac disease research.
- Experience working in or collaborating with industry.
- Experience with primary cell isolation.
- Experience with culturing induced pluripotent stem cells and cardiomyocytes, as well as evaluation of functional endpoints relevant to cardiomyocyte biology.
- Experience with in vivo evaluations of heart biology in rodents.
- Experience using electronic lab notebooks.
- Eligible for Employee Referral Bonus