Principal Scientist - Molecular and Cellular Biologist, Cancer Vaccines and Immunotherapeutics
- Employer
- Pfizer
- Location
- La Jolla, California
- Start date
- Jul 30, 2021
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- Discipline
- Science/R&D, Biology, Biotechnology, Immunology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Best Places to Work
ROLE RESPONSIBILITIES
The Cancer Vaccines and Immuno-therapeutics department within Pfizer’s Oncology R&D organization is developing state-of-the-art immunotherapy regimens to benefit cancer patients. This Principal Scientist position will join a highly skilled and dedicated Molecular and Cellular Biology (MCB) team to apply expertise and leadership advancing novel immunotherapies from preclinical research through early clinical development. Specific responsibilities will include:
- Serving as MCB line representative on one or more immune cell engager antibody programs.
- In collaboration with cross-functional team, design next generation immune cell engaging antibodies (bi-specifics, tri-specifics); engineer expression vectors; express and purify antibodies at small scale; develop and perform in vitro cell-based and biophysical characterization assays.
- Apply scientific expertise in antibody drug discovery to advance programs.
- Work effectively with cross-functional teams, providing specialized knowledge and influence to maximize program speed and success.
- Potentially serve as Research Project Leader on an immune cell engager program.
- Contribute expertise in molecular and cellular biology to other Cancer Vaccines and Immuno-therapeutics programs to aid development and advancement of the portfolio.
- Provide ideas and perform research to identify new opportunities to develop immune-mediated therapeutics.
- Directly manage a team of 1-3 experimental scientists, maximizing employee productivity, engagement, and professional development.
- Strengthen line and department’s overall immuno-oncology capabilities and expertise.
- Contribute to preparation of drug development and regulatory documents.
- Effectively communicate strategy, methodology, progress, and challenges to multiple stakeholders and partners.
- Participate in collaboration with external academic and industry partners to advance programs and develop new ones.
BASIC QUALIFICATIONS
- Ph.D. in molecular and cellular biology, immunology, or related field.
- At least 5 years of post-Ph.D. experience in the area of antibody drug discovery for the treatment of cancer.
- Demonstrated productivity working as part of cross-functional team.
PREFERRED QUALIFICATIONS
- Expertise with a variety of different molecular cloning techniques.
- Expertise developing and performing cell-based assays.
- Expertise in performing in vitro antibody characterization assays.
- Experience in generating stable cell lines.
- Experience in cancer vaccines and/or oncolytic viruses.
- A strong record of achievement, including advancement of cancer drug projects and/or publications.
- Outstanding communication and ability to both influence and motivate other.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Required to work with BSL2 infectious viruses (e.g., Vaccinia, adenovirus, lentivirus, etc.) and must receive and maintain required vaccinations or provide satisfactory proof of same.
Other Job Details
- Last Date to Apply for Job: August 19, 2021
- Eligible for Employee Referral Bonus
- Eligible for Relocation Package
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