Scientist, In vivo Gene Therapy

Cambridge, MA
Jul 30, 2021
Required Education
Bachelors Degree
Position Type
Full time

What You Will Achieve

Pfizer’s Rare Disease Research Unit (RDRU) is focused on developing therapeutic solutions for patients with rare disorders. We are seeking a laboratory-based Scientist to be part of an interdisciplinary team to execute and oversee preclinical studies in rodents and non-human primates (NHP) in support of Pfizer’s gene therapy portfolio. This role will have a strong focus on gene therapy delivery related to rare neurological and metabolic diseases. The individual will work independently in the laboratory as well as a member of cross-functional and collaborative project teams. The Scientist will use their scientific judgment in making decisions within their area of expertise and proactively gather input from colleagues to ensure efficient and timely execution of mouse and/or NHP studies. This Scientist should have advanced expertise in at least one of the following areas: animal protocol management, mouse/NHP tissue processing, and in vivo study design/execution.

How You Will Achieve It

  • Execute preclinical studies to evaluate AAV vector expression in mice
  • Tissue sample processing and generate quality data for in vivo AAV biodistribution studies
  • Support high-priority projects in the RDRU portfolio
  • Work with Contract Research Organizations to manage NHP study protocols
  • Coordinate with other Pfizer Research and Development teams, especially the drug safety department to ensure timely execution of NHP studies



  • BS or MS in life science with 6+ years of relevant industry experience, or recent Ph.D. graduate.
  • Experience with animal colony management
  • Hands-on experience with mouse handling and tissue dissection
  • Basic understanding of AAV biology
  • Strong communication skills to coordinate the deliverables of multiple cross-functional teams
  • Self-motivated and the ability to work independently including data analysis and troubleshooting of experimental results


  • Experience with NHP study protocol execution and/or management
  • Hands-on experience with molecular biology and/or biochemical assay techniques (eg. DNA/RNA extraction, ELISA etc.)

Other Job Details

  • Eligible for Employee Referral Bonus

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development