Associate Director/Director, Translational Research

South San Francisco, CA
Jul 30, 2021
Biotech Bay
Required Education
Position Type
Full time


DEPARTMENT: Translational Research

REPORTS TO: Eleni Venetsanakos

Day One (NASDAQ: DAWN) was founded to address a critical unmet need: children with cancer are being left behind in a cancer drug development revolution. Our name was inspired by the “The Day One Talk” that physicians have with patients and their families about an initial cancer diagnosis and treatment plan. We aim to re-envision cancer drug development and redefine what’s possible for all people living with cancer—regardless of age—starting from Day One.


  • Contribute to translational research in oncology, including designing and executing strategies for patient selection and biomarker development across all pipeline programs
  • Drive in vitro and in vivo pharmacology studies from design to completion to support hypothesis-driven patient stratification strategies, identify and validate novel biomarkers, and guide potential combination strategies in both pediatric and adult oncology programs
  • Develop translational research plans for biomarker selection and validation, and successfully implement key biomarkers into clinical trials in collaboration with the Clinical Development group
  • Select, establish, and manage relationships with external CROs and academic collaborators for translational research
  • Support development of companion diagnostic assays in collaboration with clinical, diagnostic, and regulatory groups
  • Actively participate in internal and external scientific meetings through presentations and critically evaluate both internal results and emerging scientific literature



  • PhD in cell biology, cancer biology, pharmacology, or a related scientific field


  • 7+ years of drug development in biopharmaceutical industry
  • Demonstrated solid scientific background and understanding of small molecule oncology drug development, patient indication and combination strategies
  • Experience in developing pharmacodynamic, predictive and exploratory biomarkers for oncology drug development programs


  • Experience and demonstrated skills in translating mechanistic biology, in vitro and in vivo pharmacology studies into clinical biomarker, patient stratification, and combination strategies
  • Experience managing CROs and consultants; experience working in partnership with academic collaborators
  • Ability to analyze, interpret, and clearly communicate data and its impact on program strategy
  • Excellent oral and written communication and presentation skills, and ability to work as effective team member in highly collaborative, fast-paced start-up biotech work environment
  • Strong analytical skills and problem solving capabilities
  • Excellent organization skills and ability to manage projects to meet key deliverables
  • Ability to work independently and interact effectively in cross-functional collaborative teams 


The preceding job description has been designed to indicate the general nature and level of work performed by employees within this specification.  It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.