Biophysics Scientist I

San Francisco, CA, United States
Jul 29, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
The Position

We are seeking a highly skilled and motivated Scientist with expertise in Biophysics to join Nurix's Discovery team.

You will provide scientific leadership in Nurix's biophysics efforts to help support our hit identification, hit-to-lead and structural biology efforts. You will play a key role in collecting and interpreting biophysical assay data for ongoing discovery programs, but also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to project teams and senior management.

  • Ph.D. in Biochemistry, Biophysics, or a related field, or an M.S. with at least three years of relevant work experience, or a B.S. with five years of relevant work experience
  • Experience using biophysical techniques to analyze protein-small molecule interactions
  • Hands on experience with Surface Plasmon Resonance (SPR) or Grating-Coupled Interferometry (GCI)
  • Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
  • Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team
  • Good fit with Nurix culture

Application Process

Please include a two-page research summary that highlights the above qualifications along with your resume when you submit your application.


Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.