Senior Research Scientist I - Protein Purification Process Development

Location
Oceanside, CA
Posted
Jul 29, 2021
Ref
2399433
Required Education
Associate Degree
Position Type
Full time
Senior Research Scientist I - Protein Purification Process Development
United States - California - Oceanside

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Senior Research Scientist I - Protein Purification Process Development

Oceanside, CA

Gilead Sciences, Inc. is a research-based biopharmaceutical company founded in 1987. Together we deliver lifesaving therapies to patients in need. With the commitment and drive you bring to the workplace every day, you will be part of a team that is changing the world and helping millions of people live healthier, more fulfilling lives. Our worldwide staff is a close community where you can see the tangible results of your contributions, where every individual matters, and everyone has a chance to enhance their skills through ongoing development. Our scientific focus has resulted in marketed products that are benefiting hundreds of thousands of people, a pipeline of late-stage drug candidates, and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

Gilead has an opportunity for an experienced candidate in our Biologics Drug Substance Development group at our Oceanside facility in Southern California. We are seeking a motivated, teamoriented individual with scientific expertise in purification process development and oversite of GMP drug substance manufacturing. The successful candidate will be expected to lead phase appropriate development projects for monoclonal antibodies and other recombinant protein modalities, demonstrate leadership in the laboratory and independently champion technology development projects.

Essential Duties and Job Functions:
  • Hands-on technical leadership of all aspects of purification process development including process definition, optimization, scale-up and validation/characterization.
  • Lead the development, characterization and troubleshooting of drug substance manufacturing unit operations such as centrifugation, normal flow filtration, chromatography operations, tangential flow filtration, and virus inactivation/removal with limited supervision.
  • Direct research associates and members of project teams in the planning and execution of laboratory experimentation, considering appropriate economic, regulatory and safety factors.
  • Provide GMP manufacturing support for process transfers from development to clinical/commercial manufacturing facilities including document review, discrepancy resolution, technical troubleshooting and identifying opportunities for future process improvements.
  • Represent purification process development on cross-functional teams and effectively communicate ideas, project goals and results to team members across functional roles/departments.
  • Author and review development reports, regulatory filings, and process validation and characterization reports.
  • Work in collaboration to advance the development of economical, state-of-the-art techniques to purify, characterize and manufacture drug substances.
  • Make contributions to scientific literature and conferences through publication and presentation of research results.
  • Demonstrate technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and strategy. Proactively identify issues and develop solutions in a collaborative multidisciplinary environment.
  • Be self-motivated and organized, familiar with the relevant literature, and enjoy scientific investigation and thinking.


Knowledge, Experience and Skills:
  • A broad understanding of purification process development for monoclonal antibodies, recombinant protein proteins and/or other biologics modalities is required. The ability to demonstrate hands on experience in this area is expected.
  • Familiarity with Pilot Plant and GMP manufacturing operations including technology transfer, documentation review and technical troubleshooting.
  • Excellent verbal/written communication skills and interpersonal skills.
  • Demonstrated ability to work in a collaborative environment with a problem-solving spirit.
  • Experience in determining objectives and approaches to assignments, including making key decisions to direct projects and ensure timelines are met.


Minimum Qualifications:
  • PhD + 3 years industry experience in a relevant scientific discipline or BS/MS degree with extensive industry experience.


Gilead is an equal opportunity employer

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans\' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law' poster.

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PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

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