Scientist (Immunology)

Location
Richmond, CA
Posted
Jul 28, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

JOB SUMMARY:   

Our Client is seeking an innovative scientist to support the development of our gene-edited cellular therapies. The successful candidate will contribute to the advancement of a next-generation CAR-Treg therapy. This is a highly-collaborative, hands-on position that requires creativity, organization, leadership, attention to detail, excellent communication and presentation skills, and a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced and offers the opportunity to work and publish at the cutting edge of genome editing and cell-based therapy research.

ESSENTIAL FUNCTIONS: 

  • Utilize immunological experience for the development of a next-generation CAR-Treg therapy.
  • Independently design, execute and interpret critical in vitro and in vivo experiments to answer scientific questions. (eg. Treg suppression assays, proliferation, activation and phenotypic characterization using multi-parameter flow cytometry, cytokine analysis etc…)
  • Perform, analyze, and document laboratory procedures with exceptional attention to detail
  • Work cross-functionally with other research teams and with other departments to drive programs forward into development
  • May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program
  • Present results internally to R&D and executive leadership teams and externally at scientific conferences
  • Publish results in leading scientific journals and contribute to related patent filings

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

  • Ph.D. in Immunology, Cellular Biology or a relevant field
  • A strong background in immunology is preferred
  • Fresh PhDs will be considered. Level will be determined by experience, skills, and ability
  • Experience with human immune cell processing from buffy coats and/or leukopaks
  • Experience characterizing the phenotype and function of immune cells using in vitro assays and molecular characterization (eg. Multi-color flow cytometry, activation assays, suppression assays, ELISA, Luminex, reporter assays etc…)
  • Understanding of biology supporting adoptive cellular therapy as a therapeutic modality
  • Aseptic cell culture expertise is a must

OTHER QUALIFICATIONS:

  • Experience with CAR-T or CAR-Treg cells is a plus
  • Experience with lentiviral, AAV or electroporation of primary cells is a plus
  • Experience in molecular biology including cloning, quantitative PCR, and next generation sequencing methods is a plus
  • Hands-on experience in genome engineering is a plus
  • Experience in drug development from product inception to IND is a plus