Senior Scientist, CRISPR Diagnostics

COMPANY

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences is advancing disease detection and treatment using its novel CRISPR systems that can deliver on the promise of precision medicine across diagnostics and therapeutics. Furthermore, Mammoth's CRISPR technology platform will enable new solutions in life science research, healthcare, agriculture, biodefense and more.

Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.

The Diagnostics team is advancing our CRISPR-based DETECTR™ platform to address unmet needs across the continuum of testing. From laboratories to the home, our mission is to democratize diagnostics with CRISPR.

OPPORTUNITY

Mammoth is seeking a Senior Scientist, CRISPR Dx to drive development of new DETECTR™ assays. The ideal candidate will have experience with a range of genomic, molecular and biochemical techniques applied to in vitro assay development. Further, the candidate will be comfortable working as part of a team, be highly motivated, and display excellent time management skills.

KEY RESPONSIBILITIES

• Explore and innovate novel technologies from ideation to product development
• Conduct proof of concept and feasibility of novel approaches to develop and improve CRISPR diagnostic assays
• Conduct technical experiments for sample processing, nucleic acid amplification, and related assays to develop sample-to-answer CRISPR diagnostic assays
• Perform data analysis of experiments and generate summaries for group meetings
• Document information by maintaining daily logs and equipment record books
• Resolve problems by examining and evaluating data and selecting corrective steps
• Complete projects by assisting project team and attending and participating in group and project meetings
• Stay current in the field by participating in educational opportunities and reading relevant publications

REQUIRED QUALIFICATIONS

• PhD in molecular biology, biochemistry, genomics or associated field
• Postdoc plus 3 years or 5 years of industry experience
• Expertise in genomics and molecular biology, including principles of nucleic acid chemistry, primer design, technologies for gene target amplification using isothermal amplification methods and guide RNA design
• Strong background in assay innovation, optimization and development
• Experience with non-commercial nucleic acid extraction methods
• Working knowledge of design of experiments methodologies

PREFERRED QUALIFICATIONS

• Experience with in vitro diagnostics development
• Experience working with CRISPR nucleases
• Experience evaluating clinical samples with in vitro diagnostics
• Experience in Python, JMP, and/or other data analysis tools
• Exceptional skills in communication, presentation, data analysis, and interpretation
• Highly motivated and detail-oriented with the ability to think creatively towards efficient problem solving

BENEFITS

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver and ergonomics benefits
• 401(k) with company matching

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.