Associate Scientist, Downstream Process Development

Location
Austin, TX, USA
Posted
Jul 26, 2021
Ref
304040
Hotbed
Lone Star Bio
Required Education
Bachelors Degree
Position Type
Full time
Company Description:

Molecular Templates is a clinical-stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics. Our proprietary biologic drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases. MTEM currently has multiple clinical-stage ETB candidates in development including MT-5111, TAK-169, and MT-6402. Additional preclinical compounds derived from our ETB platform technology are being advanced toward clinical development. Additional information about Molecular Templates can be obtained at www.mtem.com.

Position Overview:

Molecular Templates is seeking an experienced and highly motivated professional to support downstream process development. The Associate Scientist will be responsible for working with fellow team members to develop robust, efficient, and scalable methods for protein purification/manufacture. This position will perform functions related to downstream process development of recombinant biologics, including experimentation involving protein purification, cell lysis, clarification, chromatography, ultrafiltration, diafiltration and filling. Additional activities will include solution preparation, equipment maintenance and calibration, data management, report authoring, and review of manufacturing processes. This position will also aid in identifying continuous process improvement areas and technology transfer. This will require excellent technical, analytical and organizational skills, along with adherence to written and verbal instructions, and accurate and timely completion of experimental records.

Job Responsibilities:
  • Contribute to development of downstream processes for biologic manufacturing
  • Perform protein purification experiments and analysis for downstream process development. This includes but is not limited to: buffer and solution preparation; cell lysis; various filtration methods; centrifugation; chromatography; column packing and packed bed qualification; various sterilization methods; vialing and labeling; process data recording and trending.
  • Works on problems of limited scope. Follows standard practices and procedures in analyzing situations or data from which answers can be readily obtained.
  • Builds stable working relationships within group
  • Conduct limited characterization of protein products, impurities, and protein purification using common laboratory techniques
  • Maintain detailed experimental records. Complete required documentation in an accurate and timely manner, adhering to written procedures and regulatory requirements.
  • Review and revise established protocols and SOPs related to drug development, such as process development and optimization techniques. This may also include developing and optimizing assays, conducting limited literature search of research study protocols and reports, regulatory documents, and other potential resources.
  • Conduct general laboratory duties, including washing glassware, ordering supplies, and maintaining inventory e.g. buffer and basic laboratory equipment
  • Assist with non-complex projects, such as laboratory sanitization and organization or implementation of new instrumentation, as needed
  • Support technology transfer of downstream process internally and externally
  • Occasional preclinical manufacture (lab scale) of biologics for formulation, characterization, etc.
  • Support downstream manufacturing investigations through scale-down studies and experimental investigations
  • Author technical reports and process descriptions for internal review

Qualifications:
  • Degree in Biological Sciences/Chemical Engineering/Biological Engineering/Chemistry field or similar field of study
  • Degree plus minimum years of relevant industry experience: AS + two (2) years, or BS plus experience
  • Minimum of one (1) year experience in laboratory setting conducting or supporting protein purification methods
  • Demonstrated experience in downstream processing activities/protein purification, required
  • Experience in biopharmaceutical industry, preferred
  • Experience with HPLC, preferred
  • Experience with statistical, multivariate analysis and JMP software, preferred
  • Excellent written and verbal communication skills
  • Excellent computer skills with knowledge of spreadsheet and word processing
  • Excellent problem-solving and analytical skills applied to investigations
  • Excellent organizational, time-management and multi-tasking skills
  • Ability to follow written and verbal instruction and work under supervision
  • Ability to work in a fast-paced, team environment
  • Ability to lift 30 lbs and must be able to stand, crouch, sit, bend, or stretch for extended periods of time
  • Must possess flexibility to work varying schedules to support operations, such as occasional 12-hour shift or night shift


Reporting Structure:

This position currently has no supervisory responsibilities. This position reports to Senior Scientist, Downstream Process Development.

Molecular Templates celebrates and supports our differences and is proud to be an Equal Employment Opportunity employer. We do not discriminate based upon race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, veteran status, disability, or any other legally protected characteristic.

MTEM is committed to providing reasonable accommodations for qualified individuals. If you need assistance with your application due to a disability, you may contact us at: careers@mtem.com.

By submitting a resume for consideration, applicants verify that they have read MTEM's Applicant Privacy notice. https://www.mtem.com/privacy-policy

Molecular Templates Inc https://mtem.isolvedhire.com