Senior Principal Scientist / Principal Scientist, Myeloid Biology

Redwood City, California
Jul 25, 2021
Required Education
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies.  Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

We are seeking a highly motivated and experienced Principal Scientist or Sr. Principal Scientist with deep immunology and immuno-oncology drug discovery and development experience to join the Myeloid Biology team as part of the Immunology and Stromal Biology Discovery group within the TME TRC. The individual will be part of a dynamic and matrixed research team responsible for supporting all aspects of drug discovery and development. They will work collaboratively with drug discovery, predictive science, translational and clinical teams to advance molecules and further mechanistic understandings of myeloid biology in the TME. The qualified candidate will bring extensive knowledge in immunology, myeloid biology and drug development to the team.

Core Responsibilities:

  • Deliver novel therapies that modulate myeloid cells within the TME

  • Contribute to shaping and implementing research strategy that delivers an innovative Immunology and Stromal Biology portfolio within the TME TRC

  • Ensure that key programs are aligned with overall research strategies and that appropriate activities are prioritized

  • Comprehend  competitive drug discovery/development landscape, including bridging evolving patient need with emerging scientific breakthroughs to enable drug discovery targeting the TME

  • Leverage subject matter expertise to identify opportunities and sources of portfolio growth (including from internal and external innovation)

  • Contribute knowledge and expert opinions across functions, locally and globally

  • Support a culture of rigorous data-driven decision-making that rewards truth-seeking behavior

  • Mentor and directly manage scientist


  • PhD or MD/PhD in immunology, cancer biology, immuno-oncology, myeloid biology or equivalent advanced biology degree

  • 5-8+ years of industry experience, with a proven track record in target validation and drug discovery

  • Strong background in biologics and/or small molecule drug discovery, including evidence of subject matter expertise through publications in the field or inventorship in patents

  • Experience in bringing biologic and/or small molecule programs from preclinical research through to IND submission

  • Experience in studying the TME (with emphasis on myeloid populations) a plus

  • Working knowledge of all functional areas of drug development including toxicology, translational biology and early clinical development

  • Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate and accept calculated risks to make informed decisions



Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.