Scientist II, Clinical Pharmacology

Location
San Francisco, CA, United States
Posted
Jul 24, 2021
Ref
5137-341-R
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Position Overview

Nektar has an exciting opportunity for a Scientist II, Clinical Pharmacology to join their team.

We are recruiting a highly motivated scientist to drive clinical pharmacology and pharmacokinetics activities in support of early and late stage clinical programs in immune-oncology and immunology. The candidate will assist in developing and applying clinical pharmacology and biomarker strategies for small molecules and biologics from Phase 1 first in human through Phase 3 and NDA/BLA filings. The candidate will be responsible for execution of development plans, and for defining the relationship between drug exposure and efficacy/safety measures to select the optimal dosing regimen in close collaboration with the pharmacometrics team. Our group emphasizes a collegial, collaborative environment and has a strong record of scientific innovation.

Essential duties and responsibilities:
  • Provide clinical pharmacology expertise during study execution
  • Plan and conduct hands-on non-compartmental and compartmental PK/PD data analysis, collaborate with pharmacometricians in the modeling of emerging PK and PK/PD data, interpret, summarize, and present the results to internal and external project teams.
  • Develop clinical pharmacology study designs and collaborate with key stakeholders/teams to write study protocols, informed consent forms, statistical analysis plans, IB, and clinical study reports, ensuring that designs and documents meet global regulatory and compliance requirements and project timelines
  • Prepare CRO and site training
  • Represent clinical pharmacology function in cross-functional study teams
  • Participate in writing publications and making scientific presentations consistent with development strategies
  • Develop and maintain collaborative working relationships with colleagues within and outside the department
Qualifications / Experience:
  • A minimum of 4 years' related experience and a PharmD or PhD degree with emphasis on clinical pharmacology, pharmacokinetics, or a related scientific discipline. Exceptional non-PhDs with demonstrated capabilities and/or significant experience will be considered
  • Demonstrated technical proficiency, problem-solving capabilities, scientific creativity, and desire to work collaboratively
  • Knowledge of contemporary PK, population PK, QSP modeling concepts, data analysis, and interpretation
  • Hands-on experience with data analysis, non-compartmental and compartmental PK/PD analysis using Phoenix WinNonlin and/or R.
  • Desire and curiosity to acquire scientific knowledge for portfolio projects
  • Previous experience in biologics and knowledge of human immune system and lymphocyte functions for development of immuno-oncology drugs
  • Flexible, results-oriented, and demonstrated ability to work in a fast-paced, timeline-driven environment
  • Strong computer skills with a proficiency in Word, Excel, PowerPoint
  • Excellent written and verbal communication skills and ability to convey complex technical information clearly
We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.