Manager, Neuroscience & Ophthalmology Therapeutic Area Genetics

We are looking for a scientist in our Neuroscience & Ophthalmology Therapeutic Area Genetics team. You will take on responsibilities for the design, execution, and interpretation of genetics studies focusing on neurological diseases, as part of the Therapeutic Area Genetics team, and in collaboration with the Analytical Genetics team and the genome sequencing and informatics production teams. We lead genetics discovery projects, support new programs/collaborations, and support the execution of overall scientific strategy in neurological disease genetics. Goals of the team will be to apply genetics to target discovery, selecting indications for drug programs, and patient/disease stratification through genetic analyses.

In this role, a typical day might include the following:

• Work with a multidisciplinary genetics team consisting of human genetics scientists, bioinformaticians, statistical geneticists, and other required staff to design, execute, and interpret genetics studies related to neurological diseases for the Center. Collaborate with external partners and internal Regeneron scientists in such efforts.
• Work with research and clinical colleagues at Regeneron to introduce human genetics evidence and studies into current research plans and to support drug development efforts.
• Provide human genetics expertise and consult on projects within other R&D departments at Regeneron including therapeutic focus area teams in Neuroscience, precision medicine, and early and late clinical development.
• Survey the literature and conferences for discoveries and findings from the broader genetics community. Integrate such findings into study opportunities and considerations internally.
• Communicate and report study findings and analyses with leadership, administration, and collaborators.

This job might be for you if you:

• Have a strong work ethic and are proactive in providing solutions, foster scientific collaborations and drive projects forward.
• Value teamwork and team excellence. With your sleeves rolled up, you work on current problems while thinking of future solutions.
• Bring innovative thinking to the projects at hand.
• Desire to pursue genetic discovery in a deadline-oriented, multi-disciplinary environment.

To be considered for this role, you must have a PhD in computational biology, computational genetics, bioinformatics or computer science with at least 3 years of experience in human genetics research and a translational genetics focus. Prior experience in neurogenetics studies, preferred. Demonstrated ability to design and lead human genetics studies delivering novel genetic findings and medically relevant gene discoveries in a team-based environment. Familiarity with statistical genetics and experience leading a breadth of study designs and analyses spanning family and Mendelian studies, population genotype-phenotype association studies. Involvement in or use of large-scale WES/WGS data sets such as GO-ESP, 1,000 Genomes Project, CHARGE consortium, Centers for Mendelian Genomics, ExAC. Experience with multiple platforms (chip-based genotyping, WES & WGS, Sanger, custom capture targeted sequencing, etc) as well as other genomic profiling technologies (microarrays, RNASeq, etc). Experience with genetic analyses involving complex loci (e.g. HLA, 17q21.31) and relevant methods and tools, preferred. Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations. Familiarity with clinical genetics and various genetic models of disease.

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Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.