RA I/II

Location
Emeryville, CA
Posted
Jul 24, 2021
Discipline
Science/R&D, Research
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
This role supports the Payload Engineering group within the Vector and Product Development Unit. You will report to a Principal Scientist within the Payload team and work in collaboration with their manager and other research associates and scientists on the team and within the greater V&P unit to design, construct and validate the function of AAV cassettes for various disease indications. They will play an integral part in building novel therapeutics for a range of disease targets utilizing a variety of intervention strategies including, gene replacement, siRNA, and antibody production.
Responsibilities:
  • Lab Activities: 80%
  • Supports the design and construction of AAV genomic DNA cassettes through molecular DNA cloning techniques.
  • Development and execution of in vitro assays to test the expression and function of constructed plasmids.
  • Communication and Scientific Administrative Tasks: 20%
  • Data interpretation, analysis, and presentation. Detailed record-keeping in an electronic lab notebook.
  • Contribute scientific ideas and knowledge in departmental and cross-functional tea meetings.
  • Effectively present findings at departmental and cross-functional team meetings.
  • Engage in study design for various programs.
  • Communicate effectively with management to achieve departmental goals.
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Qualifications
  • BS/MS in biology, biotechnology, microbiology, biochemistry, life sciences, or related field.
  • Experience:
  • 1+ years of experience preferred
  • Prior experience with similar techniques and responsibilities in an academic or industry setting is preferred.
  • Skills:
  • Molecular DNA cloning
  • PCR  DNA amplification and isolation techniques
  • Cell Culture
  • Transformation/Transfection/Transduction
  • Gel electrophoresis and DNA purification
  • ELISA/Western blot analysis experience desired
  • Sequencing sample preparation, analysis, and plasmid map design experience desired
  • Proficiency in Microsoft Office
  • Ability to communicate efficiently, adapt, and work within a team
  • Physical Requirements of the Role:
  • In lab and lab support activities may require occasional maneuvering of items of 25 lbs. during operations and/or storage of consumables.
  • Prolonged periods of standing or sitting at the laboratory bench.
  • During COVID-19, this person will need to be in the lab up to five days a week and adhere to the 4DMT Covid protocols and policy.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities